J Korean Assoc Oral Maxillofac Surg.  2006 Jun;32(3):216-221.

The expression of FGF-5 and FGF-7 in the cyclosporin a-induced gingival hyperplasia

Affiliations
  • 1Department of Orthodontics, College of Dentistry, Seoul National University, Korea.
  • 2Department of Oral and Maxillofacial Surgery, College of Medicine, Hallym University, Korea. epker@chollian.net
  • 3Department of Oral and Maxillofacial Surgery, College of Medicine, Eulji University, Korea.

Abstract

Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.

Keyword

Cyclosporin-A; Gingival hyperplasia; FGF-5; FGF-7

MeSH Terms

Collagen
Connective Tissue
Cyclosporine*
Fibroblasts
Gingival Hyperplasia*
Humans
Immunohistochemistry
In Situ Hybridization
Mast Cells
Organ Transplantation
RNA, Messenger
Transplants
Collagen
Cyclosporine
RNA, Messenger
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