Korean J Anat.  1999 Jun;32(3):269-278.

Expression pattern of transforming growth factors observed immunohistochemically in fetal rat

• Chae HS
• Ko MI
• Yoon SH
• Kim SS
• Kim KY
• Lee WB

Abstract

The roles of TGF-beta1, beta2 and beta3 according to gestational ages and histodifferentiation were studied using immunohistochemistry with rat fetuses. 1. From day 14 to 21 of fetal rat, all the TGF-beta1, beta2 and beta3 were expressed in endocardium, myocardium, bronchiole, tunica intima of blood vessles, mucosa and serosa of intestine, striated muscle, hepatic capsule, hepatic hemopoietic cells, meninges, epidermis and dermis. 2. From day 14 to 21 of fetal rat, TGF-beta1 was not expressed in the smooth muscle of blood vessel and intestinal tract, alveolar cell and renal tubular cell. TGF-beta2 was not expressed in the smooth muscle of blood vessel and intestinal tract and alveolar cell. TGF-beta3 was not expressed in osteocyte, alveolar cell, and basement membrane of renal cuboidal epithelial cell. And TGF-betas expressed especially in early or late gestational age and the degree of expression increased or decreased with gestational age. 3. The TGF-beta1, beta2 and beta3 were expressed in tissues originated from 3 germ layers except several tissues, and those originated from mesoderm exhibited strong expression. The TGF-beta1 was expressed more widely than TGF-beta2 and beta3 during gestation. In summary, TGF-beta1, beta2 and beta3 were considered as important control factors of cell to cell interaction in the morphogenesis of tissues during fetal development.

Keyword

transforming growth factors; fetal rat; Histogenesis

MeSH Terms

Animals
Basement Membrane
Blood Vessels
Bronchioles
Cell Communication
Dermis
Endocardium
Epidermis
Epithelial Cells
Fetal Development
Fetus
Germ Layers
Gestational Age
Immunohistochemistry
Intestines
Meninges
Mesoderm
Morphogenesis
Mucous Membrane
Muscle, Smooth
Muscle, Striated
Myocardium
Osteocytes
Pregnancy
Rats*
Serous Membrane
Transforming Growth Factor beta
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Transforming Growth Factor beta3
Transforming Growth Factors*
Tunica Intima
Transforming Growth Factor beta
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Transforming Growth Factor beta3
Transforming Growth Factors