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Role of neuron and non-neuronal cell communication in persistent orofacial pain

Iwata K, Shinoda M

It is well known that trigeminal nerve injury causes hyperexcitability in trigeminal ganglion neurons, which become sensitized. Long after trigeminal nerve damage, trigeminal spinal subnucleus caudalis and upper cervical spinal...
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Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction

Li Y, Jung NY, Yoo JC, Kim Y, Yi GS

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development...
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Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells

Hu D, Zou H, Han T, Xie J, Dai N, Zhuo L, Gu J, Bian J, Yuan Y, Liu X, Liu Z

Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis...
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Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells

Kang BH, Min HS, Lee YJ, Choi B, Kim EJ, Lee J, Kim JR, Cho KH, Kim TJ, Jung KC, Park SH

Analysis of the T-cell receptor (TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for...
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Ezrin is an Essential Marker for Metastasis of Gynecologic Cancer

Choi SD

  • KMID: 2365471
  • J Korean Soc Menopause.
  • 2012 Aug;18(2):81-93.
Ezrin, a membrane cytoskeleton linking protein, is a member of ezrin/radixin/moesin (ERM) that regulates cell shape, motility and cell to cell interaction via linking the contractile elements of the cell...
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Stimulation of Chondrogenic Differentiation of Mesenchymal Stem Cells

Yu DA, Han J, Kim BS

  • KMID: 1426153
  • Int J Stem Cells.
  • 2012 May;5(1):16-22.
The methods for cartilage repair have been studied so far, yet many of them seem to have limitations due to the low regenerative capacity of articular cartilage. Mesenchymal stem cell...
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Human leukocytes regulate ganglioside expression in cultured micro-pig aortic endothelial cells

Cho JH, Kim JS, Lim MU, Min HK, Kwak DH, Ryu JS, Lee JT, Kim SU, Kim CH, Kim CH, Koo DB, Chang KT, Choo YK

Gangliosides are ubiquitous components of the membranes of mammalian cells that are thought to play important roles in various cell functions such as cell-cell interaction, cell adhesion, cell differentiation, growth...
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Optimal Condition of Microporous Membrane for Bone Marrow Stromal Cell Allotransplantation to Stimulate Wound Healing in Vitro

Lee ES, Kim MJ, Han SK, Hong ST, Kim WK

  • KMID: 2322265
  • J Korean Soc Plast Reconstr Surg.
  • 2010 Sep;37(5):509-518.
PURPOSE: Major drawbacks of conventional bone marrow stromal cells (BSCs) transplantation method are mainly caused by direct transplanted cell to host cell interactions. We hypothesized that separation of the transplanted...
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Pathogenesis of rheumatoid arthritis

Kim JM, Kim HY

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disorder, characterized by synovitis and severe joint destruction. Many mechanisms are considered to be implicated in the development and progression of...
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Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages

Lee SM, Kim WJ, Suk K, Lee WH

BACKGROUND: APRIL, originally known as a cytokine involved in B cell survival, is now known to regulate the inflammatory activation of macrophages. Although the signal initiated from APRIL has been...
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Pathogenesis and pathophysiology of pulmonary arterial hypertension

Chang SA

  • KMID: 2259197
  • Korean J Med.
  • 2010 Jan;78(1):14-19.
Pulmonary arterial hypertension (PAH) is a rare disease with progressive pathology in pulmonary arteries. Although we lack full understanding of PAH pathophysiology, a variety of vascular components are known to...
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CD137-CD137 Ligand Interactions in Inflammation

Kwon B

The main stream of CD137 studies has been directed to the function of CD137 in CD8+ T-cell immunity, including its anti-tumor activity, and paradoxically the immunosuppressive activity of CD137, which...
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The Role of Activated Hepatic Stellate Cells in Liver Fibrosis, Portal Hypertension and Cancer Angiogenesis

Lee JS, Kim JH

Although hepatic stellate cells, which are liver specific pericytes, have been recognized within the vasculature of the sinusoid for more than one hundred years, the biology and function of these...
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Expression and Function of Plexin A1 in Rheumatoid Synoviocytes

Yoon HJ, Kim HS, Kwok SK, Cho CS, Kim WU

Objective: To investigate the expression and function of plexin A1, a transmembrane protein involving cell survival and cell-to cell interaction, in the rheumatoid synoviocytes. Methods: Immunohistochemical staining using anti-plexin A1 antibody...
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Expression of Cytokines in Coculture Model with Epithelial Cells and Fibroblasts of Nasal Polyp

Kim SW, Cho JS, Park JK, Lee KH, Cha CI

  • KMID: 1977236
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 Feb;50(2):134-138.
BACKGROUND AND OBJECTIVES: Nasal polyposis is a chronic inflammatory disease characterized histologically by edematous fluid with sparse fibrous cells, few mucous glands and proliferation of stromal and epithelial cells. There...
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Current Status of Immunotherapeutic Strategies for Central Nervous System Tumors

Yang MY, Khan-Farooqi H, Prins RM, Liau LM

  • KMID: 2189078
  • J Korean Neurosurg Soc.
  • 2006 Oct;40(4):217-226.
Malignant gliomas are the most common type of primary brain tumor and are in great need of novel therapeutic approaches. Advances in treatment have been very modest, significant improvement in...
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Distinctive Pattern of Gene Expression in Intestinal and Diffuse Gastric Cancer on cDNA Microarray

Oh CA, An SI, Cho YU, Lee KY, Kim SJ, Hur YS, Choi SK, Hong KC, Shin SH, Kim KR, Woo ZH, Lee SJ

  • KMID: 2210131
  • J Korean Surg Soc.
  • 2005 Apr;68(4):277-287.
Molecular investigations have provided evidence of the involvement of multiple genetic alterations in gastric carcinogenesis. Regarding the clinical, epidemiological and genetic aspects, well and poorly differentiated gastric adenocarcinoma exhibit some...
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Adhesion of CD40-stimulated Germinal Center B Cells to HK Cells Employs the CD11a/CD18-CD54 Interactions

Lee J, Choe J

BACKGROUND: The molecular basis of follicular dendritic cells (FDC)-germinal center (GC) B cell interaction is largely unknown, although this cellular interaction is thought to be important for the whole process...
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Interaction of Mesenchymal Stem Cells and Osteoblasts for in vitro Osteogenesis

Kim H, Lee JH, Suh H

It has recently been reported that bone marrow-derived mesenchymal stem cells (MSCs), which are systemically administrated to different species, undergo site-specific differentiation. This suggests that the tissue specific cells may...
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Transforming Growth Factor-beta is a Possible Paracrine Mediator in the Human Endometrial Decidualization

Park DW, Choi DS, Kim MR, Hwang KJ, Jo MY, Ahn SH, Min CK, Ryu HS

  • KMID: 2235702
  • Korean J Fertil Steril.
  • 2003 Mar;30(1):65-75.
OBJECTIVES: To investigate the role of TGF (Transforming growth factor-beta) involved in the paracrinic communication during decidualization between UEC (uterine epithelial cells) and USC (uterine stromal cells), we have employed...
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