Korean J Fertil Steril.
2006 Mar;33(1):35-44.
Expression of Inhibin in the Whole-body gamma-irradiated Mouse Ovary
- Affiliations
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- 1The Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea.
- 2Laboratory of Toxicogemonics, Department of Life Science, Hanyang University, Seoul 133-791, Korea. ydyoon@hanyang.ac.kr
Abstract
OBJECTIVE
The purposes of the present study were to investigate the effect of gamma-radiation on the expression of inhibin-alpha proteins and genes for inhibin alpha, betaA, and betain the ovary.
METHODS
Immature mice were whole-body gamma-irradiated with 25% of a lethal dose. At time 0, 3, 6, 12, and 24 hours after the irradiation,the ovaries were collected and used for immunohistochemistry for inhibin-alpha, and RT_PCR for inhibin-alpha, betaA, and betaB.
RESULTS
The expression of the immunoreactive inhibins-alpha was maintained at 12 hours post-irradiation and reduced thereafter. The expression of inhibin-alpha mRNA was significantly increased with the time after the irradiation. However there were no significant changes in the expression of betaA and betaB mRNAs.
CONCLUSION
It might be thought that inhibin acts as one of the regulatory factors in the gamma-radiation-induced follicular atresia in mice
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