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Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey

An H, Cho DW, Lee SE, Yang YS, Han SC, Lee CJ

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Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease

An H, Lee H, Yang S, Won W, Lee CJ, Nam MH

  • KMID: 2517475
  • Exp Neurobiol.
  • 2021 Jun;30(3):222-231.
  • doi: 10.5607/en21013
Parkinson’s disease (PD) is the most prevalent neurodegenerative motor disorder. While PD has been attributed to dopaminergic neuronal death in substantia nigra pars compacta (SNpc), accumulating lines of evidence have...
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Differential Proximity of Perisynaptic Astrocytic Best1 at the Excitatory and Inhibitory Tripartite Synapses in APP/PS1 and MAOB-KO Mice Revealed by Lattice Structured Illumination Microscopy

An H, Koh W, Kang S, Nam MH, Lee CJ

  • KMID: 2517474
  • Exp Neurobiol.
  • 2021 Jun;30(3):213-221.
  • doi: 10.5607/en21015
Bestrophin-1 (Best1) is a GABA- and glutamate-permeable, Ca 2+ -activated Cl - channel, which is mainly expressed in astrocytes and localized at the microdomain or perisynaptic junction of the tripartite...
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An Atypical Choroid Plexus Papilloma Initially Manifestating as Radicular Symptoms

Lee CJ, Kim JH, Kim Y, Lee JB, Ryu B

A 29-year-old woman had 1-month history of back pain radiating into lower extremities, motor weakness, and sensory abnormalities in both lower extremities. Contrast-enhanced spinal magnetic resonance imaging (MRI) revealed a...
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Insights on Bridging Stent Grafts in Fenestrated and Branched Aortic Endografting

Yoon WJ, Rodriguez VM, Lee CJ

Major branches of the aortic arch and visceral aorta pose a particular challenge for endovascular repair of aneurysms involving these regions. To preserve perfusion through these essential branches, fenestrated and...
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Sodium-glucose Co-transporter 2 Inhibitors: a New Path for Heart Failure Treatment

Oh J, Lee SH, Lee CJ, Kang SM

Results from cardiovascular outcome trials (CVOT) with 5 different sodium-glucose cotransporter 2 inhibitors (SGLT2i; empagliflozin, canagliflozin, dapagliflozin, ertugliflozin, sotagliflozin), initially developed for their glucose-lowering effect by blocking tubular glucose reabsorption...
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Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways

Li X, Jin F, Lee HJ, Lee CJ

In the present study, kaempferol, a flavonoidal natural compound found in Polygonati Rhizoma, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. A...
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Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling

Shin HY, Han KS, Park HW, Hong YH, Kim Y, Moon HE, Park KW, Park HR, Lee CJ, Lee K, Kim SJ, Heo MS, Park SH, Kim DG, Paek SH

  • KMID: 2515812
  • Exp Neurobiol.
  • 2021 Apr;30(2):120-143.
  • doi: 10.5607/en21004
Central neurocytoma (CN) has been known as a benign neuronal tumor. In rare cases, CN undergoes malignant transformation to glioblastomas (GBM). Here we examined its cellular origin by characterizing differentiation...
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The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB

An H, Heo JY, Lee CJ, Nam MH

  • KMID: 2515811
  • Exp Neurobiol.
  • 2021 Apr;30(2):113-119.
  • doi: 10.5607/en21007
The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the...
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Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment

Won J, Kazan HH, Kwon J, Park M, Ergun MA, Ozcan S, Choi BY, Heo WD, Lee CJ

In the era of COVID-19 outbreak, various efforts are undertaken to develop a quick, easy, inexpensive, and accurate way for diagnosis. Although many commercial diagnostic kits are available, detailed scientific...
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Acute Cerebral Artery Occlusion by Direct Tumor Embolus

Lee DK, Lee MA, Hwang BW, Lee CJ, Lim SC, Ha SW, Ahn SH

In acute stroke, emboli are mostly composed of thrombi from artery, cardiac chamber, valve and vein. Non-thrombotic emboli are sometimes difficult to identify the origin. According to the increased number...
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Culturing at Low Cell Density Delays Cellular Senescence of Human Bone Marrow-Derived Mesenchymal Stem Cells in Long-Term Cultures

Kim SN, Choi B, Lee CJ, Moon JH, Kim MK, Chung E, Song SU

Background and Objectives: Mesenchymal stem cells (MSCs) have immense therapeutic potential for treating intractable and immune diseases. They also have applications in regenerative medicine in which distinct treatments do not...
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The Effects of Human Bone Marrow-Derived Mesenchymal Stem Cell Conditioned Media Produced with Fetal Bovine Serum or Human Platelet Lysate on Skin Rejuvenation Characteristics

Kim SN, Lee CJ, Nam J, Choi B, Chung E, Song SU

Background and Objectives: Human mesenchymal stem cell-conditioned medium (MSC-CM) is produced using mesenchymal stem cell culture technology and has various benefits for the skin, including wrinkle removal, skin regeneration, and...
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Small Molecule Drug Candidates for Managing the Clinical Symptoms of COVID-19: a Narrative Review

Yun C, Lee HJ, Lee CJ

Towards the end of 2019, an atypical acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and subsequently named Coronavirus disease 2019...
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Eriodictyol Inhibits the Production and Gene Expression of MUC5AC Mucin via the IκBα-NF-κB p65 Signaling Pathway in Airway Epithelial Cells

Yun C, Lee HJ, Lee CJ

In this study, we investigated whether eriodictyol exerts an effect on the production and gene expression of MUC5AC mucin in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with...
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A Deafness Associated Protein TMEM43 Interacts with KCNK3 (TASK-1) Two-pore Domain K+ (K2P) Channel in the Cochlea

Jang MW, Kim TY, Sharma K, Kwon J, Yi E, Lee CJ

  • KMID: 2522145
  • Exp Neurobiol.
  • 2021 Oct;30(5):319-328.
  • doi: 10.5607/en21028
The TMEM43 has been studied in human diseases such as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) and auditory neuropathy spectrum disorder (ANSD). In the heart, the p.(Ser358Leu) mutation has...
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Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein

Youk H, Kim M, Lee CJ, Oh J, Park S, Kang SM, Kim JH, Ann Sj, Lee SH

Background and Objectives: The relationship between metabolic stress, inflammation, and cardiovascular disease is being studied steadily. The aim of this study was to evaluate the effect of palmitate (PA) and...
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Diclofenac Inhibits Phorbol Ester-Induced Gene Expression and Production of MUC5AC Mucin via Affecting Degradation of IkBα and Translocation of NF-kB p65 in NCI-H292 Cells

Jin F, Li X, Lee HJ, Lee CJ

In this study, diclofenac, a non-steroidal anti-inflammatory drug, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. The human respiratory epithelial NCI-H292 cells...
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Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus

Li X, Jin F, Lee HJ, Lee CJ

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the...
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Towards Understanding Tuberculosis- Related Issues in North Korea: A Narrative Review of North Korean Literature

Lee CJ, Lee S, Kim HJ, Kang YA

Background: North Korea is one of the 30 countries with the highest tuberculosis (TB) and drug-resistant TB burdened. To understand the medical issues and research trends associated with TB in...
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