J Breast Cancer.  2008 Sep;11(3):109-115. 10.4048/jbc.2008.11.3.109.

Expression of HER-2/neu and Paxillin in Ductal Carcinoma in situ, Invasive Ductal Carcinoma with Ductal Carcinoma in situ and Mucinous Carcinoma

• Han SW
• Choi YY
• Woo HD
• Sohn DM
• Bae SH
• Gang GH
• Kim SY
• Baek MJ
• Lim CW
• Lee MS
• Kim CH
• Lee MH
• Rho JH
• Cho HD
• Oh MH
• Kim EH
• Cho MS

• KMID: 1485103
• DOI: http://doi.org/10.4048/jbc.2008.11.3.109

Abstract

PURPOSE
We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ (DCIS), invasive ductal carcinoma with ductal carcinoma in situ (IDC with DCIS) and mucinous carcinoma. METHODS: To evaluate the expression of HER-2/neu and paxillin, the immunohistochemical staining was performed for 13 cases of DCIS, 13 cases of IDC with DCIS and 6 cases of mucinous carcinoma. RESULTS: The DCIS and IDC were associated with infiltration of the inflammatory cells, especially in the comedo type and solid type of tumor. In cases with infiltration of the inflammatory cells, HER-2/neu and paxillin were strongly expressed. When comparing the expression level of HER-2/neu from adjacent normal tissue between DCIS and IDC with DCIS, expression of HER-2/neu was similar to that of normal tissue adjacent to DCIS. However, in the adjoining normal ductal epithelial cells, paxillin was highly expressed in cells of all of the tumor types, and especially for IDC with DCIS. HER-2/neu and paxillin were not expressed in mucinous carcinoma cells in all cases. CONCLUSION: HER-2/neu in the DCIS and IDC with infiltration of inflammatory cells shows higher expression than non-inflammatory DCIS and IDC. If normal duct epithelial cells show a high level of HER-2/neu expression, the epithelial cells have a high probability of transformation into anaplastic cells. However, paxillin appears to have no value as a prognostic factor. The difference of expression of HER-2/neu between IDC with DCIS and DCIS suggests a different origin of tumor cells. The growth pattern of mucinous carcinoma cell is different from the that of DCIS or IDC cell, which grow slowly.

Keyword

HER-2/neu; Paxillin; Ductal carcinoma in situ; Invasive ductal carcinoma; Mucinous carcinoma

MeSH Terms

Adenocarcinoma, Mucinous
Carcinoma, Ductal
Carcinoma, Intraductal, Noninfiltrating
Epithelial Cells
Mucins
Paxillin
Mucins
Paxillin

Figure

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  Fig 1 The HER-2/neu showed score 3 pattern in solid type DCIS portion and invasive portion (×40).

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  Fig 2 The Paxillin showed score 3 pattern in solid type DCIS portion and invasive portion in area in Fig 1 (×40).

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  Fig 3 The HER-2/neu showed score 0 in mucinous carcinomab (×40).

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