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Tyrosine phosphorylation of paxillin may be involved in vascular smooth muscle contraction

Fang LH, Cho KS, Lee SJ, Ahn HY

  • KMID: 1580807
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):211-217.
Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated...
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The role of the alpha4 integrin-paxillin interaction in regulating leukocyte trafficking

Rose DM

  • KMID: 1094143
  • Exp Mol Med.
  • 2006 Jun;38(3):191-195.
The movement of leukocytes from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the pathogenesis of inflammatory and autoimmune diseases. Integrins are...
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Expression of HER-2/neu and Paxillin in Ductal Carcinoma in situ, Invasive Ductal Carcinoma with Ductal Carcinoma in situ and Mucinous Carcinoma

Han SW, Choi YY, Woo HD, Sohn DM, Bae SH, Gang GH, Kim SY, Baek MJ, Lim CW, Lee MS, Kim CH, Lee MH, Rho JH, Cho HD, Oh MH, Kim EH, Cho MS

PURPOSE: We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ (DCIS), invasive ductal carcinoma with ductal carcinoma in situ (IDC with DCIS) and...
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Focal adhesion linker proteins expression of fibroblast related to adhesion in response to different transmucosal abutment surfaces

Moon YH, Yoon MK, Moon JS, Kang JH, Kim SH, Yang HS, Kim MS

PURPOSE: To evaluate adherence of human gingival fibroblasts (HGFs) to transmucosal abutment of dental implant with different surface conditions with time and to investigate the roles of focal adhesion linker...
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Vav3, a GEF for RhoA, Plays a Critical Role under High Glucose Conditions

Sha J, Na J, Lee JO, Kim N, Lee SK, Kim JH, Moon JW, Kim SJ, Lee HJ, Choi JI, Park SH, Kim HS

BACKGROUND: The role of small GTPase molecules is poorly understood under high glucose conditions. METHODS: We analyzed the expression pattern of Vav3 in skeletal muscle C2C12 cells under high glucose culture...
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Ca2+/Calmodulin-Dependent and -Independent Mechanisms are Involved in Angiotension II-induced Contraction of Rat Aortic Smooth Muscle

Lee BD, Choi SJ, Kim SJ, Lim SW

BACKGROUND: Angiotensin II (Ang II) appears to play important roles in the pathogenesis of hypertension. However, the mechanism by which Ang II induces vascular smooth muscle contraction is not...
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The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts

Kim EC, Lee DY, Lee MH, Lee HJ, Kim KH, Leesungbok R, Ahn SJ, Park SJ, Yoon JH, Jee YJ, Lee SC, Lee SW

BACKGROUND: We aimed to determine the effect of fibronectin (FN)-immobilized microgrooved titanium (Ti) on human gingival fibroblast proliferation, gene expression and protein expression. METHODS: Photolithography was used to fabricate the microgrooved...
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Influence of Potassium Channel Blockage on Early Hypoxic Neuronal Excitability

Kim JH, Moon HJ, Kim JH, Kwon TH, Chung HS, Park YK

OBJECTIVE: Potassium channels are ubiquitously expressed in all organisms and constitute the most diverse class of ion channels. Their action is regulated by various factors and is involved in neuronal...
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betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin

Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS

  • KMID: 1111408
  • Exp Mol Med.
  • 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,...
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