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Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases

Zhang B, Chang JY, Lee MH, Ju SH, Yi HS, Shong M

Mitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPRmt) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response...
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A study on the pathway for severe emergency patients visiting emergency departments to establish regionalization of emergency medical services in Busan, Ulsan, and Gyeongsangnam-do regions

Lee MH, Kim KH, Yun HJ, Yeom SR, Ryu JH

  • KMID: 2550063
  • J Korean Soc Emerg Med.
  • 2023 Dec;34(6):550-557.
Objective: This study assessed the characteristics of medical utilization by analyzing the pathway of severe emergency patients visiting emergency departments in the three regions. Methods: The study was conducted based on...
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A Predictive Model for Distant Metastasis in Patients With Breast Cancer Based on Machine Learning

Kwon HJ, Lee MH, Joo SY, Lee K, Lee SA, Kim SK, Kim I

Purpose: Breast cancer starts as a local disease, but can metastasize to distant organs. In this study, we described an easy-to-use tool for predicting distant metastases based on clinical characteristics...
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A Case of Injection Laryngoplasty in a Patient With Delayed-Onset Aspiration Following Near Total Laryngectomy

Jung SJ, Lee MH, Jin SM, Lee SH

Near total laryngectomy (NTL) is a procedure that creates a biological shunt between the airway and the neopharynx. Compared to total laryngectomy, NTL shunt performed in a suitable patient gives...
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A Case of Ramsay Hunt Syndrome Showing Central Findings due to Brainstem Involvement

Lee MH, Kim MB

Ramsay Hunt syndrome occurs when the varicella zoster virus reactivates. Classic findings include the triad of facial paralysis, otic pain and herpetic lesions due to the pathogenesis associated with anterograde...
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Balancing Bleeding Risk and Thromboembolic Complications in Elderly Chronic Subdural Hematoma Patients Undergoing Burr Hole Trephination : A Multicenter Retrospective Cohort Study and Literature Review

Eun J, Ahn S, Lee MH, Choi JG, Park JS, Cho CB, Kim YI

Objective : Chronic subdural hematoma (CSDH) patients using antithrombotic agents (AT) at high risk for cardiovascular disease are increasing. The authors aimed to analyze the factors influencing outcome by targeting...
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Omega-3 fatty acids upregulate Nrf2 expression and attenuate apoptosis, inflammation, and fibrosis in a rat model of cyclosporine-induced nephropathy

Lee JY, Son YK, Lee MH, Lee SM, Kim SE, An WS

Background: Cyclosporine A (CsA)-induced kidney injury is characterized by renal impairment with inflammatory cell infiltrations, apoptosis, fibrosis, and hypoxic injury. It is not clear whether omega-3 fatty acids (O-3 FAs),...
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The Direction of Neurosurgery to Overcome the Living with COVID-19 Era : The Possibility of Telemedicine in Neurosurgery

Lee MH, Jang SR, Lee TK

Objective : Due to the implementation of vaccinations and the development of therapeutic agents, the coronavirus disease 2019 (COVID-19) pandemic that started at the end of 2019 has entered a...
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Delayed Detection of a 5-Aminolevulinic Acid In Vivo: A Case of Metastatic Breast Cancer

Kim HM, Lee MH, Lee TK

A 44-year-old female patient who had been diagnosed with breast cancer visited our oncology department. She had developed right-side weakness and mild dysarthria, and MRI revealed a 4-cm cysticenhancing lesion...
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Skeletal and dentoalveolar effects of different types of microimplant-assisted rapid palatal expansion

Choi HY, Lee SM, Lee JW, Chung DH, Lee MH

Objective: To evaluate the following null hypothesis: the skeletal and dentoalveolar expansion patterns in the coronal and axial planes are not different with two different types of microimplant-assisted rapid palatal...
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Extremely Rare CT and MRI Findings of Peritoneal Leiomyoma Mimicking Hepatic Mass: A Case Report

Woo J, Choi SY, Kim HK, Lee JE, Lee MH, Lim S

Leiomyoma is a common benign tumor from smooth muscle cells, mostly in the uterus. Peritoneal leiomyomas (PLs) are extremely rare and mostly reported as disseminated peritoneal leiomyomatosis. However, to the...
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3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases

Lee JY, Lee SO, Kwak AW, Chae SB, Cho SS, Yoon G, Kim KT, Choi YH, Lee MH, Joo SH, Park JW, Shim JH

The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive...
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Clinical Implications of DeviceDetected Atrial Fibrillation in Cardiac Resynchronization Therapy

Yoon M, Oh J, Chun KH, Yu HT, Lee CJ, Kim TH, Pak HN, Lee MH, Joung B, Kang SM

Background and Objectives: Atrial fibrillation (AF) is associated with decreased cardiac resynchronization therapy (CRT) benefits compared to sinus rhythm (SR). Effective biventricular (BiV) pacing is a determinant of CRT success,...
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Exercise Frequency Reduction Is Associated With Higher Risk of Infection in Newly Diagnosed Diabetes: A Nationally Representative Cohort Study

Lim Y, Kim HJ, Yoon SS, Lee SJ, Lee MH, Park H, Park SJ, Jeong S, Han HW

Background: Exercise is an important method to control the progression of diabetes. Since diabetes compromises immune function and increases the risk of infectious diseases, we hypothesized that exercise may affect...
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Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases

Park SH, Lee EK, Yim J, Lee MH, Lee E, Lee YS, Seo W

The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different...
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The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Survey About Specific Clinical Scenarios (Version 2023.1)

Kim MS, Go SI, Wee CW, Lee MH, Kang SG, Go KO, Kwon SM, Kim W, Dho YS, Park SH, Seo Y, Song SW, Ahn S, Oh HJ, Yoon HI, Lee SW, Lee JH, Cho KR, Choi JW, Hong JB, Hwang K, Park CK, Lim DH, KSNO Guideline Working Group

Background During the coronavirus disease 2019 (COVID-19) pandemic, there was a shortage of medical resources and the need for proper treatment guidelines for brain tumor patients became more pressing. Thus, the...
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The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Recommendation Using the Delphi Method (Version 2023.1)

Kim MS, Go SI, Wee CW, Lee MH, Kang SG, Go KO, Kwon SM, Kim W, Dho YS, Park SH, Seo Y, Song SW, Ahn S, Oh HJ, Yoon HI, Lee SW, Lee JH, Cho KR, Choi JW, Hong JB, Hwang K, Park CK, Lim DH, KSNO Guideline Working Group

Background During the coronavirus disease 2019 (COVID-19) pandemic, the need for appropriate treatment guidelines for patients with brain tumors was indispensable due to the lack and limitations of medical resources. Thus,...
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A Phase II Trial of S-1 and Oxaliplatin in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane (KCSG-BR07-03)

Lee DW, Keam B, Lee KS, Ahn JH, Sohn J, Ahn JS, Lee MH, Kim JH, Lee KE, Kim HJ, Kim SY, Park YH, Ock CY, Lee KH, Han SW, Kim SB, Im YH, Chung HC, Oh DY, Im SA

Purpose This single-arm phase II trial investigate the efficacy and safety of S-1 plus oxaliplatin (SOX) in patients with metastatic breast cancer. Materials and Methods Patients with metastatic breast cancer previously...
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Intraoperative Computed Tomography for Identifying Bleeding Focus in Spontaneous Rupture of Uterine Artery during Pregnancy: A Case Report

Kim S, Kim Y, Kyeong KS, Kim SH, Lee MH, Cho HY, Kyung MS, Kang JB

A 35-year-old pregnant woman, para 0, who had previous medical history of lymphoma, visited to our hospital at 18 weeks and 2 days of gestation with chief complaint of suprapubic...
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Feasibility of Ultrashort Echo Time T2* Mapping in Comparison With T2 Mapping for Quantitative Evaluation of Meniscal Degeneration

Ryu J, Lee SH, Choi SY, Shin MJ, Lee MH, Chung HW

Purpose: This study aimed to assess the feasibility of ultrashort echo time (UTE)-T2* mapping in comparison with T2 mapping for quantitative evaluation of meniscal degeneration. Materials and Methods: This study included...
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