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Correlation between the Her-2/neu Status as Determined by Immunohistochemical Analysis and the Serum Her-2/neu Concentration as Determined by the Use of ADVIA Cencaur(R) Automated Immunoassay in Breast Cancer Patients

Lee JS, Min WK, Park EH, Lim WS, Choi SL, Son BH, Kim SB, Ahn JH, Ahn SH

PURPOSE: Serum Her-2/neu is extracted from the extracelluar domain of the Her-2/neu tyrosine kinase to serum. We evaluated the correlation between the Her-2/neu status as determined by immunohistochemical analysis (IHC)...
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Expression of HER-2/neu and Paxillin in Ductal Carcinoma in situ, Invasive Ductal Carcinoma with Ductal Carcinoma in situ and Mucinous Carcinoma

Han SW, Choi YY, Woo HD, Sohn DM, Bae SH, Gang GH, Kim SY, Baek MJ, Lim CW, Lee MS, Kim CH, Lee MH, Rho JH, Cho HD, Oh MH, Kim EH, Cho MS

PURPOSE: We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ (DCIS), invasive ductal carcinoma with ductal carcinoma in situ (IDC with DCIS) and...
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The Correlation of Serum HER-2/neu and CA15-3 in Patients with Metastatic Breast Cancer

Park NK, Woo HD, Sohn DM, Kim SY, Lim CW, Choi TY, Kim JJ, Lee MH

PURPOSE: The extracellular domain (ECD) of the HER-2/neu oncoprotein, whose molecular weight is the range from the 95 kD to 105 kD, is shed into the blood from the cell...
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Amplification of the HER-2/neu Oncogene and Topoisomerase II-alpha by Chromogenic in Situ Hybridization in Breast Cancer

Kim HS, Kim BG, Cha SJ, Lee TJ, Park SJ, Lim HM, Park SI

  • KMID: 1521593
  • J Korean Surg Soc.
  • 2007 Aug;73(2):87-95.
PURPOSE: HER-2/neu is the most frequently amplified oncogene in breast cancer. Topoisomerase II-alpha is a key enzyme in DNA replication and it is a molecular target for many anti-cancer drugs...
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The gamma-Synuclein Expression in Breast Cancer and its Correlation with the Expression of the HER-2/neu Gene

Kim SR, Choi WH, Park JH, Nam ES, Cho SJ, Park CH

PURPOSE: Synuclein has been identified as an important neuroprotein for developing pathologic deposits in Alzheimer's and Parkinson's disease patients. gamma-synuclein is also known as a breast cancer-specific gene 1 thats's...
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Expression of HER-2/neu Oncoprotein in Epithelial Ovarian Cancer

Jeong DH, Kim YN, Park YM, Cho IH, Seo YJ, Son YS, Jeong SJ, Lee KB, Sung MS, Kim KT, Yoon HK

  • KMID: 2077615
  • Korean J Obstet Gynecol.
  • 2006 Jun;49(6):1258-1266.
OBJECTIVE: To evaluate the significance of the expression of HER-2/neu oncoprotein as a prognostic factor, we retrospectively examined its overexpression rates in epithelial ovarian cancer and their relationships with prognostic...
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Establishment for Reference Range of Serum HER-2/neu in Korean Healthy Women

Kim JW, Kim SY, Lee HS, Woo HD, Son DM, Lim CW, Choi TY, Jang YS, Kim JJ, Lee MH

PURPOSE: HER-2/neu oncogene is known to play a part in the process of carcinogenesis, while the biological characteristics of HER-2/neu oncoprotein include regulating cell growth and increasing the reproductionability of...
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Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors

Nam E, Lee SN, Im SA, Kim DY, Lee KE, Sung SH

  • KMID: 2270834
  • Cancer Res Treat.
  • 2005 Jun;37(3):165-170.
PURPOSE: Previous epidemiologic studies have demonstrated that nonsteroidal anti-inflammatory drugs can reduce the risk of breast cancer, and this possibly happens via cyclooxygenase (COX) inhibition. Moreover, growth factor-inducible COX-2, which...
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Expression of HER-2/neu in Gastric Adenocarcinoma

Lee IK, Choi BJ, Song BJ, Kim W, Park JS, Chang SK, Jeon HM, Lee A

  • KMID: 2210130
  • J Korean Surg Soc.
  • 2005 Apr;68(4):271-276.
PURPOSE: The HER-2 oncogene plays a role in cellular oncogenic transformation, and is related to the aggressive tumor behaviour. Several studies have addressed the prognostic and predictive roles of the...
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Correlation of the Immunohistochemical Coexpression of p53 and HER-2/neu and the Prognosis of Breast Cancer

Park JH, Kim SJ, Choi UJ, Lee KM

PURPOSE: Among the many biological parameters of breast cancer, the p53 and HER-2/neu genes, which are located on the chromosome 17, and their gene products have been studied extensively by...
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Clinical Significance of HER-2/neu Expression in Colon Cancer

Park DI, Oh SJ, Park SH, Yun JW, Kim HJ, Cho YK, Sung IK, Sohn CI, Jeon WK, Kim BI, Cho EY, Kim EJ, Chae SW, Sohn JH, Kim JJ

  • KMID: 1113358
  • Korean J Gastroenterol.
  • 2004 Sep;44(3):147-152.
BACKGROUND/AIMS: The HER-2/neu protein is involved in normal cell proliferation and tissue growth because it is extensively homologous and related to epidermal growth factor receptor. As a prognostic marker,...
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Evaluation for the Clinical Usefulness of Serum HER-2/neu Oncoprotein in Patients with Breast Cancer

Cho HJ, Lee SY, Kim JW

  • KMID: 2239050
  • Korean J Lab Med.
  • 2004 Aug;24(4):215-222.
BACKGROUND: The HER-2/neu oncogene codes a protein of the family of epidermal growth factor receptors and is amplified and/or overexpressed by 20-40% of breast cancers. The extracellular domain (ECD) has...
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Chromogenic In Situ Hybridization Analysis to Determinate HER-2/neu Status in Breast Carcinoma

Kim JY, Choi KU, Jung YJ, Kwak HS, Bae YT

  • KMID: 2096168
  • J Korean Surg Soc.
  • 2004 Jun;66(6):447-453.
PURPOSE: The determination of HER-2/neu gene amplification has become necessary for the selection of breast cancer patients to undergo anti-HER-2/neu therapy, using a humanized monoclonal antibody. Chromogenic in situ hybridization...
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The Analysis of HER-2/neu Gene Status and Correlation with Other Clinico-Pathologic Factors for Breast Cancer Using Tissue Microarray

Song CS, Kim SI, Park CH

PURPOSE: The main clinical significance of HER-2/neu gene amplification is derived from its use as (a) a prognostic indicator, (b) a predictive factor for the sensitivity to chemotherapy, and (c)...
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Clinical Correlation of HER-2/neu Overexpression in Patients with Breast Cancer

Kim SY, Kim TY, Kim JJ, Kim CH, Song OP, Lee MH, Kim EH, Cho MS

PURPOSE: Breast cancer is a common malignant tumor for Korean women. Various oncogenes have been demonstrated in malignant tumor cells. There were many reports on the relationship between the prognosis...
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The Expressions of CD117 (c-kit) and Her-2/neu in Malignant Bone and Soft Tissue Tumors

Jeong JG, Choi IS, Roh SI, Kwak CH, Kim SE, Chang HK, Kim JD

  • KMID: 2399148
  • J Korean Orthop Assoc.
  • 2004 Oct;39(6):715-721.
PURPOSE: The aim of this study was to determine the prevalence of c-kit (CD117) and Her-2/neu expressions in malignant bone and soft tissue tumors and to identify a possible predictive...
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A Clinical Analysis of PTEN Expressions in Breast Cancers

Cho HJ, Kim JS, Kim KH, Ahn CH, Park WC, Oh SJ, Jung SS, Lim KW, Im SA

  • KMID: 2166198
  • Cancer Res Treat.
  • 2003 Apr;35(2):102-108.
PURPOSE: The PTEN gene, a novel tumor suppressor, is localized to chromosome 10q23.3 and shares extensive homology with the cytoskeletal protein, tensin. A high frequency of mutations at the PTEN...
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Evaluation of Her-2/neu in Breast Cancer: Comparison of Immunohistochemistry and Polymerase Chain Reaction

Lee MJ, Jeon HJ

  • KMID: 2166197
  • Cancer Res Treat.
  • 2003 Apr;35(2):96-101.
PURPOSE: In breast cancer, Her-2/neu amplification/overexpression predicts a poor clinical outcome, and enhanced survival benefits have been reported with Her-2/neu targeted therapy. Currently, there are several methods for assessing the...
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HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization and Immunohistochemical Expression of Topoisomerase II-alpha in the Breast Cancer

Lee TJ, Oh HG, Kwon GY, Kim MK, Park ES, Yoo JH

  • KMID: 1725953
  • Korean J Pathol.
  • 2003 Feb;37(1):26-34.
BACKGROUND: Amplifications of the HER-2/neu oncogene and the Topoisomerase II-alpha gene are important determiners of the response to chemotherapy in the breast cancer. For detecting HER-2/neu amplification, fluorescent in situ...
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Characteristics of HER-2/neu Oncogene in Korean Women with Early-onset Breast Cancer by Immunohistochemistry and Fluorescence In Situ Hybridization

Choi DH, Lee MH, Ahn YH, Lee DW, Shin DB, Carter D, King BL, Haffty BG

  • KMID: 2329036
  • J Korean Breast Cancer Soc.
  • 2003 Dec;6(4):255-262.
PURPOSE: The purpose of this work was to investigate the prognostic significance of of HER-2/neu (HER-2) oncogene protein overexpression in Korean women with early-onset breast cancer by immunohistochemistry. Furthermore, the...
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