J Korean Soc Radiol.  2012 Dec;67(6):461-464. 10.3348/jksr.2012.67.6.461.

Apocrine Ductal Carcinoma In Situ of the Breast Presented Mass with Morphological Change on Follow-Up Ultrasound: A Report of Case

• Seo GY
• Kim SJ
• Park SH
• Lee SJ
• Ryu HS
• Jung YY

• KMID: 2097982
• DOI: http://doi.org/10.3348/jksr.2012.67.6.461

Abstract

Apocrine carcinoma in situ of breast is a rare, unique, and morphologically distinct type of breast carcinoma. Low-grade apocrine ductal carcinoma in situ (DCIS) and apocrine metaplasia with atypia are the pathologic spectrum of apocrine breast lesions. Differentiating these two lesions is difficult due to partial microscopic overlap. We describe a case of apocrine DCIS which presented an asymptomatic hypoechoic mass with morphological change on a follow up ultrasonography.

MeSH Terms

Breast
Carcinoma in Situ
Carcinoma, Ductal
Carcinoma, Intraductal, Noninfiltrating
Follow-Up Studies
Metaplasia

Figure

• 

  Fig. 1 A 60-year-old asymptomatic woman. A. Initial breast ultrasonography revealed a 0.7 × 0.3 × 0.3 cm sized well-circumscribed hypoechoic mass in the left breast in the direction of 3-o'clock approximately 1 cm from the nipple. B, C. Follow up ultrasonography after 1.5 year shows morphologic change with a newly developed indistinct margin, irregular shape and mild echogenic halo (B: longitudinal image, C: transverse image). D. Photomicrograph shows apocrine ductal carcinoma in situ characterized by abundant eosinophilic cytoplasm and moderate nuclear pleomorphism (Hematoxylin and Eosin, × 100). E. Photomicrograph of specimen shows a myoepithelial layer around the well-defined island of malignant cells. The neoplastic cells are negative (high molecular weight cytokeratin, × 200).

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