Yeungnam Univ J Med.  2009 Dec;26(2):143-147. 10.12701/yujm.2009.26.2.143.

A Case of Intravesical Cidofovir Treatment of BK Virus-Associated Hemorrhagic Cystitis after Allogeneic Peripheral Blood Stem Cell Transplantation

• Kang SH
• Lee HJ
• Jang YS
• Ji JH
• Lee SA
• Lee WS
• Lee JL
• Lee KH

• KMID: 1469812
• DOI: http://doi.org/10.12701/yujm.2009.26.2.143

Abstract

Hemorrhagic cystitis (HC) is a common complication after allogeneic transplantation. Early posttransplant HC occurs in association with cyclophosphamide, while later on HC results from viral infections such as polyomavirus BK (BKV) and adenovirus. We report here the case of a 57-year-old woman who received an instillation of cidofovir into the bladder for the treatment of hemorrhagic cystitis after allogeneic peripheral stem cell transplantation for her acute myeloid leukemia. Cyclophosphamide and busulfan were used as conditioning treatments. Cyclosporin was administered daily. On the 71st day after transplantation, the patient developed acute severe hemorrhagic cystitis, and BK virus was demonstrated in the urine samples using polymerase chain reaction. Her urinary symptoms did not improve in spite of palliative treatment, but a response was evident after intravesical cidofovir treatment.

Keyword

Hemorrhagic cystitis; Stem cell transplantation; Cidofovir

MeSH Terms

Adenoviridae
BK Virus
Busulfan
Cyclophosphamide
Cyclosporine
Cystitis
Cytosine
Female
Humans
Leukemia, Myeloid, Acute
Middle Aged
Organophosphonates
Palliative Care
Peripheral Blood Stem Cell Transplantation
Polymerase Chain Reaction
Polyomavirus
Stem Cell Transplantation
Stem Cells
Transplantation, Homologous
Transplants
Urinary Bladder
Busulfan
Cyclophosphamide
Cyclosporine
Cytosine
Organophosphonates