Korean J Pediatr.  2014 Dec;57(12):514-519. 10.3345/kjp.2014.57.12.514.

BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation

• Han SB
• Cho B
• Kang JH

• KMID: 2284640
• DOI: http://doi.org/10.3345/kjp.2014.57.12.514

Abstract

Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis, pediatricians outside the hemato-oncology and nephrology specialties tend to be unfamiliar with hemorrhagic cystitis and the BK virus. Moreover, no standard guidelines for the early diagnosis and treatment of BK virus-associated hemorrhagic cystitis after stem cell transplantation have been established. Here, we briefly introduce poststem cell transplantation BK virus-associated hemorrhagic cystitis.

Keyword

Cystitis; Stem cell transplantation; BK virus; Child

MeSH Terms

BK Virus
Cell Transplantation
Child
Cystitis*
Early Diagnosis
Humans
Incidence
Mesna
Nephrology
Stem Cell Transplantation*
Stem Cells
Transplants
Mesna