Korean J Pathol.  2011 Jun;45(3):315-318. 10.4132/KoreanJPathol.2011.45.3.315.

Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings

• Kim NR
• Ro JY
• Shin KH
• Paik HJ
• An JS
• Ha SY

• KMID: 1443740
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.3.315

Abstract

A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.

Keyword

Solitary fibrous tumors; Conjunctiva; Antigens, CD34; CD99; Bcl-2

MeSH Terms

Actins
Adult
Antigens, CD34
Basement Membrane
Biopsy
Chimera
Conjunctiva
Cytoplasm
Desmin
Diagnosis, Differential
Electrons
Endoplasmic Reticulum, Rough
Eosinophils
Female
Fibroblasts
Glial Fibrillary Acidic Protein
Glomus Tumor
Humans
Leiomyoma
Light
Melanoma
Meningioma
Mitochondria
Mucin-1
Muscle, Smooth
Nevus
Ribosomes
S100 Proteins
Solitary Fibrous Tumors
Vimentin
Actins
Antigens, CD34
Desmin
Glial Fibrillary Acidic Protein
Mucin-1
S100 Proteins
Vimentin