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Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate

Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ

Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS...
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Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii

Im KH, Baek SA, Choi J, Lee TS

In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl...
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Nailbed malignant melanoma in three dogs

Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination...
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Extracranial systemic antitumor response through the abscopal effect induced by brain radiation in a patient with metastatic melanoma

D'Andrea M, Reddy GK

The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic...
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Evaluation of response to stereotactic radiosurgery in patients with radioresistant brain metastases

Sayan M, Zoto Mustafayev T, Sahin B, Kefelioglu ESS, Wang SJ, Kurup V, Balmuk A, Gungor G, Ohri N, Weiner J, Ozyar E, Atalar B

PURPOSE: Renal cell carcinoma (RCC) and melanoma have been considered ‘radioresistant’ due to the fact that they do not respond to conventionally fractionated radiation therapy. Stereotactic radiosurgery (SRS) provides high-dose...
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Therapeutic Proton Beam Range Measurement with EBT3 Film and Comparison with Tool for Particle Simulation

Lee N, Kim C, Song MH, Lee SB

PURPOSE: The advantages of ocular proton therapy are that it spares the optic nerve and delivers the minimal dose to normal surrounding tissues. In this study, it developed a solid...
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Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner

Gim E, Shim DW, Hwang I, Shin OS, Yu JW

Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neurological disorders including Guillain-Barré syndrome and microcephaly. The host innate immune responses against ZIKV infection are essential for protection; however,...
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A Case of Desmoplastic Melanoma in a Patient with Parkinson's Disease

Park S, Song S, Lee S, Kim H, Baek J, Park H, Roh J

No abstract available.
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Lichen Planus Developed During the Treatment with Nivolumab in a Patient with Lung Cancer: A Case Report and Literature Review

Park E, Koo T, Jo M, Yoo J, Park J

  • KMID: 2465922
  • Korean J Dermatol.
  • 2019 Nov;57(9):551-555.
Nivolumab is a fully-humanized IgG4 monoclonal antibody that competitively binds to the programmed cell death receptor-1 protein (an immune check-point molecule) present on activated T cells. Nivolumab is approved for...
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Prognostic Significance of the Imaging Parameters of Adipose Tissue and Bone Marrow on F-18 Fluorodeoxyglucose PET/CT in Patients with Malignant Melanoma

Lee JH, Lee SM, Kim JE

PURPOSE: Fluorodeoxyglucose (FDG) uptake of bone marrow (BM) and adipose tissue is known to reflect systemic inflammatory response to cancer cell. The objective of this study was to evaluate the...
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Investigating the role of immunotherapy in advanced/recurrent female genital tract melanoma: a preliminary experience

Indini A, Di Guardo , Cimminiello C, Lorusso D, Raspagliesi F, Del Vecchio M

OBJECTIVE: immunotherapy with immune checkpoint inhibitors has become one of the standard therapeutic modalities for patients with advanced melanoma. Melanoma of the female lower genital tract is a rare and...
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Primary malignant melanoma without melanosis of the colon

Yi NH, Lee JW, Lee SH, Kim JH, Jee SR, Seol SY

Primary malignant melanoma (PMM) of the gastrointestinal tract is rare. Reported cases of PMM of the lower gastrointestinal tract typically describe anal and rectal involvement rather than colonic lesions. This...
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PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages

Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS

BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM....
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The Reappraisal of the Slide-Swing Skin Flap: A Versatile Technique for Surgical Defects

Kim MS, Lee SK, Jue MS, Park HJ

BACKGROUND: The slide-swing skin flap is a combination of transposition and adjacent skin sliding and can be used to close large, round defects with a flap that is smaller than...
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Dermoscopic Evolution of Pediatric Nevi

Cengiz FP, Yılmaz Y, Emiroglu N, Onsun N

BACKGROUND: The incidence of pediatric melanoma is very rare. Dermoscopic features help to distinguish pediatric melanoma and common nevi. OBJECTIVE: To study the evolution of dermoscopic findings in benign nevi in...
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Analysis of the Clinical Characteristics of Cutaneous Malignant Tumors: 11-year Single-center Study in Daejeon City and Chungnam Province

Oh DY, Lee HK, Jung KE, Koo DW, Lee JS

  • KMID: 2465954
  • Korean J Dermatol.
  • 2019 Sep;57(8):464-475.
BACKGROUND: The occurrence of cutaneous malignant tumors has been increasing worldwide due to changes in various environmental factors. OBJECTIVE: Our study aimed to analyze the overall tendency of clinical characteristics in...
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Anti-melanogenesis and Anti-inflammatory Effects of Cinnamomi Cortex Extract In Vitro

Park JH, Park SJ, Park KY, Kim BJ

  • KMID: 2465952
  • Korean J Dermatol.
  • 2019 Sep;57(8):448-456.
BACKGROUND: Many researchers have sought to identify safe, natural herbal extracts that exert an anti-melanogenesis effect. Cinnamomi cortex has been widely used as a herbal medicine in Asia and Europe. OBJECTIVE:...
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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis

PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene...
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A case of malignant melanoma after repeated recurrent dysplastic nevi

Jeong DK, Bae YC, Lee SJ, Kim HS, Choi YJ

Dysplastic nevus is common and affects about 10% of the northern European-descendent population. Studies over the past several decades have identified dysplastic nevi as a risk factor for malignant melanoma....
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Lichenoid Drug Eruption Developed in Melanoma Patient Treated with Nivolumab

Hong KR, Kwon R, Kim JE, Park YL, Lee SH

  • KMID: 2454380
  • Korean J Dermatol.
  • 2019 Jul;57(6):343-345.
No abstract available.
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