Obstet Gynecol Sci.  2013 May;56(3):201-204.

Primary malignant melanoma arising in a cystic teratoma

Affiliations
  • 1Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. sternum@schmc.ac.kr

Abstract

The malignant transformation of a cystic teratoma is a rare event, occurring in about 0.2% to 1.8%. Primary malignant melanoma arising from the ovary is extremely rare. A primary melanoma in an ovarian cystic teratoma originates most frequently at the dermoepidermal junction, similar to a cutaneous melanoma. Though there are no standard adjuvant regimens for the treatment of primary malignant melanoma of the ovary. We present another case report of malignant melanoma developing in cystic teratoma.

Keyword

Ovarian teratoma; Malignant melanoma

MeSH Terms

Female
Melanoma
Ovarian Cysts
Ovary
Teratoma

Figure

  • Fig. 1 Precontrast (A, C) and contrast-enhanced (B, D) computed tomography-scan images show a multi-loculated 19×15 cm cystic mass with calcification (arrow) and fat (*), suggesting a teratoma.

  • Fig. 2 There are an infiltrating area of atypical cells in the mature teratoma (A, H&E, ×100 ). The atypical cells have pleomorphic and bizarre nuclei with macronucleoli and melanin pigment (B, H&E, ×400). The tumor cells are found in the squamous epithelium lining the cystic lesion (C, H&E, ×400) showing diffuse strong positive for melan A (D) and HMB 45 (E, HMB stain ×400).


Reference

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