Obstet Gynecol Sci.  2013 May;56(3):201-204.

Primary malignant melanoma arising in a cystic teratoma

• Hyun HS
• Mun ST

Abstract

The malignant transformation of a cystic teratoma is a rare event, occurring in about 0.2% to 1.8%. Primary malignant melanoma arising from the ovary is extremely rare. A primary melanoma in an ovarian cystic teratoma originates most frequently at the dermoepidermal junction, similar to a cutaneous melanoma. Though there are no standard adjuvant regimens for the treatment of primary malignant melanoma of the ovary. We present another case report of malignant melanoma developing in cystic teratoma.

Keyword

Ovarian teratoma; Malignant melanoma

MeSH Terms

Female
Melanoma
Ovarian Cysts
Ovary
Teratoma

Figure

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  Fig. 1 Precontrast (A, C) and contrast-enhanced (B, D) computed tomography-scan images show a multi-loculated 19×15 cm cystic mass with calcification (arrow) and fat (*), suggesting a teratoma.

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  Fig. 2 There are an infiltrating area of atypical cells in the mature teratoma (A, H&E, ×100 ). The atypical cells have pleomorphic and bizarre nuclei with macronucleoli and melanin pigment (B, H&E, ×400). The tumor cells are found in the squamous epithelium lining the cystic lesion (C, H&E, ×400) showing diffuse strong positive for melan A (D) and HMB 45 (E, HMB stain ×400).

Reference

1. Crouet H, de Ranieri E, de Ranieri J. Secondary cancers arising in mature benign cystic teratomas of the ovary (dermoid cysts)Review of the literature apropos of a new case. J Gynecol Obstet Biol Reprod (Paris). 1986. 15:1055–1066.

2. Vimla N, Kumar L, Thulkar S, Bal S, Dawar R. Primary malignant melanoma in ovarian cystic teratoma. Gynecol Oncol. 2001. 82:380–383.

3. Andrews HR. Primary melanotic sarcoma of the ovary. Trans Obstet Soc. 1901. 43:228–231.

4. Moehrle M, Fischbach H, Nuessle B, Rassner G. Primary malignant melanoma arising in a cystic necrotic ovarian teratoma. Eur J Obstet Gynecol Reprod Biol. 2001. 99:268–271.

5. McNeilage LJ, Morgan J, Constable J, Jobling TW. Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. Int J Gynecol Cancer. 2005. 15:1148–1152.

6. Moon JW, Kim JY, Shin YJ, Lee MY, Choi HJ, Park JY, et al. Primary malignant melanoma arising from ovarian mature cystic teratoma: a case report and literature review. Korean J Obstet Gynecol. 2010. 53:846–850.

7. Hermann WJ Jr, Humes JJ. A compound nevus in a benign cystic teratoma of the ovary. Am J Clin Pathol. 1976. 66:54–58.

8. Otero E, Haberland J, Valdes R, Hernandez P, Cabrera D. Malignant melanoma in an ovarian dermoid cyst. Rev Chil Obstet Ginecol. 1995. 60:43–45.

9. Cronje HS, Woodruff JD. Primary ovarian malignant melanoma arising in cystic teratoma. Gynecol Oncol. 1981. 12:379–383.

10. Nanbu Y, Fujii S, Konishi I, Nonogaki H, Mori T, Woodruff JD. Primary ovarian malignant amelanotic melanoma arising in cystic teratoma. Gynecol Oncol. 1990. 37:138–142.