Korean J Vet Res.  2012 Sep;52(3):163-167.

Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs

• Chae JS
• Ahn JO
• Coh YR
• Park CW
• Youn HY

Abstract

Mosapride stimulated dietary motility was introduced because of the arrhythmogenic effect of cisapride. Cisapride, 5-HT receptor agonist, induces prolongation of QT interval. Additionally, this condition can raise the possibility of acute, "malignant" arrhythmias such as torsade de pointes. It is hard to find any reports about effects of mosapride on cardiac parameters in dogs. By confirming electrocardiogram (ECG) parameters, the surface extremity leads ECG that was obtained from the four-limb electrodes and which was recorded by an ECG recorder after administration of mosapride 3 mg/kg PO b.i.d, and mosapride 3 mg/kg with itraconazole 5 mg/kg PO b.i.d, respectively. QT interval was shortened on the days of 3, 5, and post-day 1 in both mosapride 3 mg/kg administrated group and mosapride with itraconazole group. Heart rate increased significantly. QTc was slightly prolonged in mosapride administration group and mosapride with itraconazole group. However, all dogs of QTc were in normal variation (150~250 msec). Besides, the dogs showed no side effects reported in human medicine during the administration with these drugs. Although mosapride can increase the heart rate, this study suggest that mosapride may be useful for the dogs with disorders of gastrointestinal motility because of no fatal arrhythmogenic effect inspite of administration with itraconazole in dogs.

Keyword

electrocardiogram; itraconazole; mosapride; QTc; QT interval

MeSH Terms

Animals
Arrhythmias, Cardiac
Benzamides
Cisapride
Citric Acid
Dogs
Electrocardiography
Electrodes
Extremities
Gastrointestinal Motility
Heart Rate
Humans
Itraconazole
Morpholines
Serotonin
Torsades de Pointes
Benzamides
Cisapride
Citric Acid
Itraconazole
Morpholines
Serotonin