J Vet Sci.  2006 Dec;7(4):391-395. 10.4142/jvs.2006.7.4.391.

Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs

• Kim JM
• Chung JY
• Lee SY
• Choi EW
• Kim MK
• Hwang CY
• Youn HY

• KMID: 1089489
• DOI: http://doi.org/10.4142/jvs.2006.7.4.391

Abstract

The hypoglycemic effects after oral administration of vanadium have been studied previously in many species such as rats, mice and even humans. However, there has been no prior report on the glucose lowering effect of vanadium on diabetic dogs. Therefore, the purpose of this study was to evaluate the hypoglycemic effects of oral vanadium on diabetic dogs. Diabetes mellitus in the dogs studied was induced by alloxan monohydrate intravenous injection. The dogs were divided into two groups, one was the diabetic control (DC) group (n = 4) and the other was the vanadium treated (DV) group (n = 6). Fresh water was supplied to the dogs in the DC group, but sodium metavanadate solution (0.1~0.2 mg/ml) was given to the dogs in DV group from one week after the alloxan injection. The fasting glucose levels, fructosamine and serum chemistry profiles were compared between the two groups weekly for three weeks. The fasting blood glucose levels in DV group were significantly lower than those in the DC group (p < 0.01). Fructosamine levels in the DV group were also lower than those in the DC group (p < 0.05). The serum chemistry profiles were not significantly different in comparisons between the two groups. However, the cholesterol levels were significantly lower in the DV group compared to the DC group (p < 0.05). Our findings showed that oral vanadium administration had a hypoglycemic effect on chemically induced diabetic dogs.

Keyword

alloxan; diabetes mellitus; dogs; vanadium

MeSH Terms

Alanine Transaminase/blood
Alkaline Phosphatase/blood
Animals
Aspartate Aminotransferases/blood
Blood Glucose/metabolism
Blood Urea Nitrogen
Chlorides/blood
Cholesterol/blood
Creatinine/blood
Diabetes Mellitus, Experimental/blood/*drug therapy
Dog Diseases/blood/*drug therapy
Dogs
Female
Fructosamine/blood
Hypoglycemic Agents/*pharmacology
Male
Pancreas/drug effects/pathology
Potassium/blood
Random Allocation
Sodium/blood
Triglycerides/blood
Vanadates/*pharmacology

Figure

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  Fig. 1 The blood glucose levels of the vanadium treatment (DV) groups were significantly lower than those of diabetic control (DC) group. *Significantly different compared to control group as p < 0.01.

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  Fig. 2 The fructosamine levels of the vanadium treatment (DV) groups were significantly lower than those of the diabetic control (DC) group. *Significantly different compared to control group as p < 0. 05.

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  Fig. 3 A. Normal pancreas. There are many islets (arrows). B. The pancreas of DC group. Islet is not observed. C. The pancreas of DV group. Islet is also disappeared. H&E stain, ×100.

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