Exp Mol Med.  2005 Feb;37(1):11-17.

Genetic polymorphism of CYP17 and breast cancer risk in Korean women

Affiliations
  • 1Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon, Gyeongi-do, Korea.
  • 2Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Korea.
  • 3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul, Korea.
  • 4Department of Clinical Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul, Korea.
  • 5Department of Preventive Medicine, Konkuk University College of Medicine, 322 Danwol-dong, Chungju, Chuncheongbuk-do, Korea.
  • 6Department of General Surgery, Seoul National University College of Medicine, Cancer Research Institute, 28 Yongon-dong, Chongno-gu, Seoul, Korea.
  • 7Department of Surgery, Ulsan University College of Medicine, 388-1 Pungnab-dong, Songpa-gu, Seoul, Korea.
  • 8Pan Genomics, Co., Ltd. #304 Biotechnology Incubating Center, Seoul National Univeristy, Kwanak-gu, Seoul, Korea. dhkang@snu.ac.kr

Abstract

CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association between the CYP17 polymorphism and breast cancer risk have been inconsistent. We examined the association between the MspAI polymorphism at +27 relative to the start of transcription in the 5'-untranslated region of CYP17 gene and breast cancer risk in Korean women. Four hundred and sixty-two incident cases and 337 controls were recruited from three teaching hospitals in Seoul during 1994-2001. Polymorphism of the CYP17 gene was determined by a single base extension assay. Demographic and lifestyle characteristics were identified using structured questionnaire. Age-adjusted (aOR) and multivariate odds ratios (mOR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression. The proportions of A1/A1, A1/A2 and A2/A2 genotypes among controls were 20.8%, 45.1% and 34.1%, respectively. Compared to the A1/A1 genotype, A1/A2 or A2/A2 genotype was not statistically significantly associated with overall breast cancer risk (i.e., mOR=1.01, 95% CI=0.69-1.47 and mOR=0.76, 95% CI=0.51-1.14, respectively). However, a significant association between CYP17 A2/A2 genotype and breast cancer was observed among women aged 50 years or less (mOR=0.58, 95% CI=0.34-0.99, P=0.04) and leaner women (body mass index < 22 kg/m2) (mOR=0.48, 95% CI=0.23-0.97, P=0.04). Our results suggest that genetic polymorphism in 5'-untranslated region of CYP17 might play a role in breast cancer development in Korean women among younger women aged less than 50 or leaner women with body mass index less than 22 kg/m2.

Keyword

breast neoplasms; estrogens; genotype; genetic polymorphism; steroid hydroxylases

MeSH Terms

5' Untranslated Regions/*genetics
Breast/metabolism/pathology
Breast Neoplasms/enzymology/epidemiology/*genetics
Case-Control Studies
Comparative Study
Demography
Female
*Genetic Predisposition to Disease
Genotype
Humans
Korea/epidemiology
Middle Aged
Odds Ratio
Polymorphism, Genetic/*genetics
Questionnaires
Research Support, Non-U.S. Gov't
Risk Factors
Steroid 17-alpha-Hydroxylase/*genetics
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