- Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis
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He L, Deng T, Luo H
- KMID: 2374118
- Yonsei Med J.
- 2016 Jul;57(4):879-884.
- doi: 10.3349/ymj.2016.57.4.879
PURPOSE: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a... -
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- No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population
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Ahn K, Kim E, Kwon YA, Kim DK, Lee JE, Jo SA
- KMID: 1115951
- Exp Mol Med.
- 2006 Dec;38(6):727-731.
The polymorphism at codon 129 (M129V) of the human prion protein gene (PRNP) is a known risk factor for Creutzfeldt-Jakob disease (CJD) in Caucasians. There are few reports of this... -
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- Polymorphism of a COLIA1 Gene Sp1 Binding Site in Korean Women with Pelvic Organ Prolapse
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Cho HJ, Jung HJ, Kim SK, Choi JR, Cho NH, Bai SW
- KMID: 1758618
- Yonsei Med J.
- 2009 Aug;50(4):564-568.
- doi: 10.3349/ymj.2009.50.4.564
PURPOSE: To evaluate the possible influence of G-->T substitution at the Sp1-binding site of the COLIA1 gene on the risk of pelvic organ prolapse (POP). MATERIALS AND METHODS: The study... -
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- No Evidence of an Association between A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene and Aggression in Schizophrenia in a Korean Population
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Kim YR, Lee JY, Min SK
- KMID: 1779602
- Yonsei Med J.
- 2010 Jan;51(1):27-32.
- doi: 10.3349/ymj.2010.51.1.27
PURPOSE: We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS: The sample included 61 aggressive patients as... -
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- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance
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Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD
- KMID: 1115948
- Exp Mol Med.
- 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the... -
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- Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
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Agachan B, Isbir T, Yilmaz H, Akoglu E
- KMID: 1119337
- Exp Mol Med.
- 2003 Dec;35(6):545-549.
Essential hypertension is a multifactorial disease in which genetic and enviromental factors play an important role. These factors differ in each population. As there are no existing data for the... -
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- Association between Toll-Like Receptor 9-1237T/C Polymorphism and the Susceptibility of Inflammatory Bowel Diseases: A Meta-Analysis
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Shang J, Wang X, Wang W, Pan H, Liu S, Li L, Chen L, Xia B
- KMID: 2466365
- Yonsei Med J.
- 2016 Jan;57(1):153-164.
- doi: 10.3349/ymj.2016.57.1.153
PURPOSE: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatory bowel diseases (IBDs), but the results remain conflicting. We further investigated... -
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- Genetic Polymorphism of Geranylgeranyl Diphosphate Synthase (GGSP1) Predicts Bone Density Response to Bisphosphonate Therapy in Korean Women
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Choi HJ, Choi JY, Cho SW, Kang D, Han KO, Kim SW, Kim SY, Chung YS, Shin CS
- KMID: 1126023
- Yonsei Med J.
- 2010 Mar;51(2):231-238.
- doi: 10.3349/ymj.2010.51.2.231
PURPOSE: Genetic factor is an important predisposing element influencing the susceptibility to osteoporosis and related complications. The purpose of the present study is to investigate whether genetic polymorphisms of farnesyl... -
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- Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population
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Kim YS, Hwang YJ, Kim SY, Yang SM, Lee KY, Park IB
- KMID: 2396087
- Yonsei Med J.
- 2008 Feb;49(1):58-62.
PURPOSE: Activation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2... -
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- Vitamin D receptor gene polymorphisms in breast cancer
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Buyru N, Tezol A, Yosunkaya-Fenerci E, Dalay N
- KMID: 1119338
- Exp Mol Med.
- 2003 Dec;35(6):550-555.
Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of... -
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- Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
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Wang J, Guo X, Zhang J, Song J, Ji M, Yu S, Wang J, Cao Z, Dong W
- KMID: 1798130
- Yonsei Med J.
- 2013 Nov;54(6):1353-1361.
- doi: 10.3349/ymj.2013.54.6.1353
PURPOSE: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective... -
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- Polymorphism in the promoter region of the klotho gene (G-395A) is associated with early dysfunction in vascular access in hemodialysis patients
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Kim Y, Jeong SJ, Lee HS, Kim EJ, Song YR, Kim SG, Oh JE, Lee YK, Seo JW, Yoon JW, Koo JR, Kim HJ, Noh JW, Park SH
- KMID: 1100768
- Korean J Intern Med.
- 2008 Dec;23(4):201-207.
- doi: 10.3904/kjim.2008.23.4.201
BACKGROUND/AIMS: Vascular access dysfunction is an important cause of morbidity and mortality in hemodialysis (HD) patients. Recent studies have shown that a klotho gene mutation is related to endothelial... -
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- Association of CYP2C19*2 and *3 Genetic Variants with Essential Hypertension in Koreans
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Shin DJ, Kwon J, Park AR, Bae Y, Shin ES, Park S, Jang Y
- KMID: 1414252
- Yonsei Med J.
- 2012 Nov;53(6):1113-1119.
- doi: 10.3349/ymj.2012.53.6.1113
PURPOSE: The cytochrome P450 2C19 (CYP2C19) metabolizes arachidonic acid to produce epoxyicosanoid acids, which are involved in vascular tone and regulation of blood pressure. Recent findings suggest that CYP2C19 gene... -
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- The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis
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Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT
- KMID: 1116200
- Exp Mol Med.
- 2005 Dec;37(6):553-558.
The eotaxin gene family (eotaxin, eotaxin-2 and eotaxin-3) have been implicated in the recruitment of eosinophils, basophiles and helper T (Th) 2 lymphocytes that is a central aspect of allergic... -
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- G Protein beta3 Subunit Polymorphism and Long-Term Prognosis of Functional Dyspepsia
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Chung HA, Lee SY, Lee HJ, Kim JH, Sung IK, Shim CS, Jin CJ, Park HS
- KMID: 1774560
- Gut Liver.
- 2014 May;8(3):271-276.
BACKGROUND/AIMS: A link between G protein beta3 (GNB3) polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role of GNB3 polymorphism in... -
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- Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders
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Jin EH, Shim SC, Kim HG, Chae SC, Chung HT
- KMID: 1123810
- Exp Mol Med.
- 2009 May;41(5):354-361.
- doi: 10.3858/emm.2009.41.5.040
To select candidate genes, we attempted to comparative analysis of protein levels between rheumatoid arthritis (RA) patients and healthy controls by two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization mass... -
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- Genetic polymorphism of CYP17 and breast cancer risk in Korean women
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Shin MH, Lee KM, Yang JH, Nam SJ, Kim JW, Yoo KY, Park SK, Noh DY, Ahn SH, Kim B, Kang D
- KMID: 1033096
- Exp Mol Med.
- 2005 Feb;37(1):11-17.
CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association between the CYP17 polymorphism and breast cancer risk have been inconsistent. We examined the association between... -
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- Associations between Single Nucleotide Polymorphisms of High Mobility Group Box 1 Protein and Clinical Outcomes in Korean Sepsis Patients
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Lee K, Chang Y, Song K, Park YY, Huh JW, Hong SB, Lim CM, Koh Y
- KMID: 2466359
- Yonsei Med J.
- 2016 Jan;57(1):111-117.
- doi: 10.3349/ymj.2016.57.1.111
PURPOSE: High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated the associations of a single nucleotide polymorphism... -
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- Association of Methylenetetrahydrofolate Reductase (MTHFR 677C>T and 1298A>C) Polymorphisms and Haplotypes with Silent Brain Infarction and Homocysteine Levels in a Korean Population
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Han IB, Kim OJ, Ahn JY, Oh D, Hong SP, Huh R, Chung SS, Kim NK
- KMID: 1126027
- Yonsei Med J.
- 2010 Mar;51(2):253-260.
- doi: 10.3349/ymj.2010.51.2.253
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for homocysteine metabolism. In the present study, we evaluated whether the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI... -
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