Gut Liver.  2014 May;8(3):271-276.

G Protein beta3 Subunit Polymorphism and Long-Term Prognosis of Functional Dyspepsia

• Chung HA
• Lee SY
• Lee HJ
• Kim JH
• Sung IK
• Shim CS
• Jin CJ
• Park HS

Abstract

BACKGROUND/AIMS
A link between G protein beta3 (GNB3) polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role of GNB3 polymorphism in the long-term prognosis of FD in Koreans.
METHODS
FD patients and normal healthy controls were recruited from patients who visited our center between December 2006 and June 2007. All of the subjects completed Rome III questionnaires before undergoing upper gastrointestinal endoscopy and colonoscopy. Genomic DNA was extracted for GNB3 genotyping. After 5 years, the subjects were reevaluated using the same questionnaires.
RESULTS
GNB3 825T carrier status was significantly related to FD in Koreans (p=0.04). After 5 years, 61.0% of the initial FD patients and 12.2% of the initial normal subjects were diagnosed with FD (odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to 31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798), female sex was strongly correlated with FD after 5 years (OR, 3.3; 95% CI, 1.2 to 9.1; p=0.017).
CONCLUSIONS
The T allele of GNB3 is linked to FD in Koreans but does not predict long-term prognosis. Female sex is related to a higher prevalence of FD after 5 years.

Keyword

Functional dyspepsia; G protein beta3; Polymorphism; Prognosis; Rome III

MeSH Terms

Case-Control Studies
Dyspepsia/*genetics
Female
Gene Frequency
Genotype
Heterotrimeric GTP-Binding Proteins/*genetics
Humans
Male
Middle Aged
Polymorphism, Genetic/*genetics
Prognosis
Prospective Studies
Heterotrimeric GTP-Binding Proteins