Yonsei Med J.  2010 Jan;51(1):27-32. 10.3349/ymj.2010.51.1.27.

No Evidence of an Association between A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene and Aggression in Schizophrenia in a Korean Population

Affiliations
  • 1Department of Neuropsychiatry and Stress Research Institute, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 2Department of Pharmacology, Korea University College of Medicine, Seoul, Korea.
  • 3Professor emeritus, Yonsei University, and Superintendent, Seoul Metropolitan Eunpyeong Hospital, Seoul, Korea. skmin518@yuhs.ac

Abstract

PURPOSE
We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS: The sample included 61 aggressive patients as well as 104 non-aggressive patients from psychiatric hospitals and 335 healthy volunteers in Korea. Blood samples were collected from all participants for TPH1 A218C genotyping. The patients were administered standard psychiatric interviews as well as a self-report questionnaire for anger-related traits. RESULTS: In the case-control phenotypic comparisons, there was no significant association between the aggressive patients and the TPH1 A218C polymorphism. There was no significant effect of the TPH1 genotype on the anger-related traits, or no significant interaction between the genotype and group (aggressive and non-aggressive patients). CONCLUSION: These findings suggest that TPH1 does not play a major role in aggressive behavior via anger in schizophrenic patients.

Keyword

Tryptophan hydroxylase; aggression; schizophrenia; anger

MeSH Terms

Adult
Asian Continental Ancestry Group/genetics
Female
Genetic Predisposition to Disease/genetics
Genotype
Humans
Male
Middle Aged
Multivariate Analysis
Polymorphism, Genetic/*genetics
Schizophrenia/*genetics
Tryptophan Hydroxylase/*genetics
Young Adult

Reference

1. Hafner H, Boker W. Crimes of violence by mentally abnormal offenders: a psychiatric and epidemiological study in the federal german republic. 1982. Cambridge: Cambridge University Press.
2. Wessely S. The epidemiology of crime, violence and schizophrenia. Br J Psychiatry Suppl. 1997. 8–11.
Article
3. Deater-Deckard K, Plomin R. An adoption study of the etiology of teacher and parent reports of externalizing behavior problems in middle childhood. Child Dev. 1999. 70:144–154.
4. Eley TC, Lichtenstein P, Stevenson J. Sex differences in the etiology of aggressive and nonaggressive antisocial behavior: results from two twin studies. Child Dev. 1999. 70:155–168.
5. Hudziak JJ, van Beijsterveldt CE, Bartels M, Rietveld MJ, Rettew DC, Derks EM, et al. Individual differences in aggression: genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. Behav Genet. 2003. 33:575–589.
6. Nelson RJ, Trainor BC. Neural mechanisms of aggression. Nat Rev Neurosci. 2007. 8:536–546.
Article
7. Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry. 2000. 5:32–38.
8. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry. 1999. 45:603–614.
Article
9. Rujescu D, Giegling I, Bondy B, Gietl A, Zill P, Möller HJ. Association of anger-related traits with SNPs in the TPH gene. Mol Psychiatry. 2002. 7:1023–1029.
Article
10. Lai TJ, Wu CY, Tsai HW, Lin YM, Sun HS. Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. BMC Med Genet. 2005. 6:14.
11. Nolan KA, Volavka J, Lachman HM, Saito T. An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. Psychiatr Genet. 2000. 10:109–115.
Article
12. Kim YR, Kim JH, Kim SJ, Lee D, Min SK. Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population. Eur Neuropsychopharmacol. 2008. 18:820–825.
Article
13. Kay SR, Wolkenfeld F, Murrill LM. Profiles of aggression among psychiatric patients. II. Covariates and predictors. J Nerv Ment Dis. 1988. 176:547–557.
14. Spielberger CD. State-Trait Anger Expression Inventory: professional manual. 1988. Odessa, FL: Psychological Assessment Resources.
15. Davis JM, Chen N. Dose response and dose equivalence of antipsychotics. J Clin Psychopharmacol. 2004. 24:192–208.
Article
16. Chon KK. Development of the Korean State-Trait Anger Expression Inventory. Korean J Rehabil Psychol. 1996. 3:53–69.
17. Ritsner M, Maayan R, Gibel A, Strous RD, Modai I, Weizman A. Elevation of the cortisol/dehydroepiandrosterone ratio in schizophrenia patients. Eur Neuropsychopharmacol. 2004. 14:267–273.
Article
18. Wigginton JE, Cutler DJ, Abecasis GR. A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet. 2005. 76:887–893.
Article
19. Porter RJ, Mulder RT, Joyce PR, Miller AL, Kennedy M. Tryptophan hydroxylase gene (TPHI) and peripheral tryptophan levels in depression. J Affect Disord. 2008. 109:209–212.
Article
20. Song H, Min SK. Aggressive behavior model in schizophrenic patients. Psychiatry Res. 2009. In press.
Article
21. Kim YR, Jahng JW, Min SK. Association between the serotonin transporter gene (5-HTTLPR) and anger-related traits in Korean schizophrenic patients. Neuropsychobiology. 2009. In press.
Article
22. Zhang XD, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science. 2004. 305:217.
Article
23. Zaboli G, Jönsson EG, Gizatullin R, Asberg M, Leopardi R. Tryptophan hydroxylase-1 gene variants associated with schizophrenia. Biol Psychiatry. 2006. 60:563–569.
Article
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