- Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome
-
Dussik CM, Hockley M, Grozić A, Kaneko I, Zhang L, Sabir MS, Park J, Wang J, Nickerson , Yale SH, Rall CJ, Foxx-Orenstein AE, Borror CM, Sandrin TR, Jurutka PW
- KMID: 2417277
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):96-106.
- doi: 10.5056/jnm17021
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other... -
- CITED
-
- Close
- SHARE
-
- Close
- Association Study between Tryptophan Hydroxylase 2 Gene -703G/T Polymorphism and Tardive Dyskinesia
-
Lee JH, Kang SG, Park YM, Lee HJ, Kim SJ, Kim L
- KMID: 1790745
- Korean J Schizophr Res.
- 2012 Jun;15(1):34-38.
- doi: 10.16946/kjsr.2012.15.1.34
OBJECTIVES: Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to... -
- CITED
-
- Close
- SHARE
-
- Close
- The Genetic Factors Affecting Drinking Behaviors of Korean Young Adults with Variant Aldehyde Dehydrogenase 2 Genotype
-
Kim SK, Lee SI, Shin CJ, Son JW, Ju G
- KMID: 2315914
- Psychiatry Investig.
- 2010 Dec;7(4):270-277.
OBJECTIVE: We determined whether aldehyde dehydrogenase 2 (ALDH2) activity alters the way in which drinking behaviors are affected by gene polymorphisms of other alcohol-metabolizing enzymes and serotonin-related proteins. METHODS: Through a... -
- CITED
-
- Close
- SHARE
-
- Close
- No Evidence of an Association between A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene and Aggression in Schizophrenia in a Korean Population
-
Kim YR, Lee JY, Min SK
- KMID: 1779602
- Yonsei Med J.
- 2010 Jan;51(1):27-32.
- doi: 10.3349/ymj.2010.51.1.27
PURPOSE: We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS: The sample included 61 aggressive patients as... -
- CITED
-
- Close
- SHARE
-
- Close
- Vardenafil Increases Cell Proliferation in the Dentate Gyrus through Enhancement of Serotonin Expression in the Rat Dorsal Raphe
-
Kim TS, Ko IG, Sung YH, Kim SE, Kim BK, Park SK, Shin MS, Kim CJ, Yoon SJ, Kim KH
- KMID: 1783139
- J Korean Med Sci.
- 2009 Dec;24(6):1099-1104.
- doi: 10.3346/jkms.2009.24.6.1099
This study was conducted to evaluate the effects of vardenafil (Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5-HT, serotonin) synthesis and... -
- CITED
-
- Close
- SHARE
-
- Close
- An Association Study of the A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene with Eating Disorders in a Korean Population: A Pilot Study
-
Kim YR, Woo JM, Heo SY, Kim JH, Lim SJ, Yu BH
- KMID: 2315815
- Psychiatry Investig.
- 2009 Mar;6(1):44-49.
OBJECTIVE: We examined the association between the tryptophan hydroxylase 1 (TPH1) gene and eating disorders focusing on obsessionality. METHODS: The sample included 62 women with a lifetime diagnosis of anorexia... -
- CITED
-
- Close
- SHARE
-
- Close
- Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism
-
Shim SH, Hwang BY, Kwon YJ, Jung HY, Lee BH, Kim YK
- KMID: 2341419
- J Korean Neuropsychiatr Assoc.
- 2008 Mar;47(2):142-152.
OBJECTIVES: Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Genetic and Environmental Factors on the Depression in Early Adulthood
-
Kim SK, Lee SI, Shin CJ, Son JW, Eom SY, Kim H
- KMID: 1770031
- Korean J Biol Psychiatry.
- 2008 Feb;15(1):14-22.
OBJECTIVES: The authors purposed to present data for explaining gene-environmental interaction causing depressive disorder by examining the effects of genetic factors related to the serotonin system and environmental factors such... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Chronic Alcohol Exposure on Dopaminergic and Serotonergic Neurotransmission System in Rat
-
Park SW, Lee YC, Ha EK, Kim YK, Lee YK, Chung DO, Ryu JW, Kong BG, Kim YH
- KMID: 2287358
- Korean J Psychopharmacol.
- 2005 Jan;16(1):81-90.
OBJECTIVE: This study investigates the effects of chronic alcohol exposure on rat brain THmRNA expression, TH (tyrosine hydroxylase) acitivity, and TPH (tryptophan hydroxylase) activity which are important in synthesis of... -
- CITED
-
- Close
- SHARE
-
- Close
- Fluoxetine-induced Changes on Activity of Tryptophan Hydroxylase at RBL-2H3 Cells
-
Baik SY, Jung KH, Choi MR, Yang BH, Kim SH, Choi IG, Chai YG
- KMID: 2286983
- Korean J Psychopharmacol.
- 2004 Dec;15(4):449-456.
OBJECTIVES: The aim of the present study is to explore the effect of fluoxetine on transcription, translation and activity of tryptophan hydroxylase (TPH), and intracellular level of serotonin. METHODS: The... -
- CITED
-
- Close
- SHARE
-
- Close
- No Association between Genetic Polymorphism of Tryptophan Hydroxylase A218C and Serotonin Transporter Linked Polymorphic Region and Panic Disorder
-
Choi YH, Woo JM, Park HK, Yoon KS, Cho DY, Lee MS
- KMID: 2248982
- Korean J Biol Psychiatry.
- 2004 Nov;11(2):136-145.
OBJECTIVES: Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution... -
- CITED
-
- Close
- SHARE
-
- Close
- Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats
-
Jang MH, Shin MC, Chang HK, Lee TH, Kim KH, Kim YJ, Kim CJ
- KMID: 1607347
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):5-8.
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine,... -
- CITED
-
- Close
- SHARE
-
- Close
- Immunochemical Characterization of Brain and Pineal Tryptophan Hydroxylase
-
Chung YI, Park DH, Kim M, Baker H, Joh TH
- KMID: 648309
- J Korean Med Sci.
- 2001 Aug;16(4):489-497.
- doi: 10.3346/jkms.2001.16.4.489
Recombinant mouse tryptophan hydroxylase (TPH) was expressed in Escheri-chia coli, using a bacterial expression vector and has been purified to homogeneity by sonication followed by Sepharose 4B column chromatography and... -
- CITED
-
- Close
- SHARE
-
- Close
- Polymorphism of Tryptophan Hydroxylase Gene in Alcohol Dependent Patients
-
Hong JB, Lee SI, Shin CJ, Kim H, Chi KW, Chung IW
- KMID: 2364341
- J Korean Neuropsychiatr Assoc.
- 2001 Jul;40(4):718-726.
OBJECTIVES: This study was performed to explore the association of tryptophan hydroxylase(TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity... -
- CITED
-
- Close
- SHARE
-
- Close
- An Association Study of Schizophrenics and Their Clinical Variables with Tryptophan Hydroxylase Gene Polymorphism
-
Cho HS, Lee SP, Toh KY, Paik IH
- KMID: 2340371
- J Korean Neuropsychiatr Assoc.
- 1999 Sep;38(5):1130-1136.
OBJECTIVES: The genetic polymorphism of tryptophan hydroxylase (TPH) the rate-limiting enzyme in the biosynthesis of serotonin, has been to be related with various psychiatric disorders such as bipolar disorders.... -
- CITED
-
- Close
- SHARE
-
- Close
