Korean J Obstet Gynecol.
2005 May;48(5):1306-1312.
Association of the CYP17 gene polymorphism with the risk of PCOS in Korean women
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea. chess1@unitel.co.kr
- 2Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
- 3Mirae and Heemang Obstetrics and Gynecology Clinic, Seoul, Korea.
- 4Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate whether polymorphism of CYP17 gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women.
METHODS
The 86 PCOS patients and 75 controls were enrolled. Blood samples were collected from 86 patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited on the control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype.
RESULTS
In women with A1A1 genotype, there was increased PCOS risk and this difference was statistically significant (OR 2.2 (CI 1-4.7)).
CONCLUSION
The results suggest that the CYP17 A1A1 genetic polymorphism might be associated with PCOS risk in Korean women.
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