Korean J Fertil Steril.  2006 Jun;33(2):97-104.

Association of the COMT Gene Polymorphism with the Risk of PCOS in Korean Women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea. jylee@kuh.ac.kr
  • 2Department of Obstetrics and Gynecology, College of Medicine, Konyang University, Daejun, Korea.
  • 3Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.

Abstract


OBJECTIVE
To investigate whether polymorphism of Catechol-O-methyltransferase (COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women.
METHODS
One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype.
RESULTS
In women with COMT(LL) genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51).
CONCLUSION
The results suggest that the COMT(LL) genetic polymorphism might be associated with PCOS risk in Korean women.

Keyword

COMT; PCOS; Polymorphism

MeSH Terms

Catechol O-Methyltransferase
Consensus Development Conferences as Topic
Female
Genotype
Humans
Menstruation
Polycystic Ovary Syndrome
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Catechol O-Methyltransferase
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