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A Novel APTX Variant and Ataxia with Oculomotor Apraxia Type 1

Manzoor H, Bukhari I, Wajid M, Zhang Y, Zhang H, Brüggemann N, Klein C, Shi Q, Naz S

No abstract available.
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Immunization of BALB/c mice with Brucella abortus 2308DeltawbkA confers protection against wild-type infection

Li ZQ, Gui D, Sun ZH, Zhang JB, Zhang WZ, Zhang H, Guo F, Chen CF

Brucellosis is a zoonotic disease that causes animal and human diseases. Vaccination is a major measure for prevention of brucellosis, but it is currently not possible to distinguish vaccinated animals...
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Biomechanical Study of 3 Osteoconductive Materials Applied in Pedicle Augmentation and Revision for Osteoporotic Vertebrae: Allograft Bone Particles, Calcium Phosphate Cement, Demineralized Bone Matrix

Jia C, Zhang R, Wang J, Zhang B, Zhang H, Kang L, Zhou L, Shen C

Objective: This study assessed biomechanical properties of pedicle screws enhanced or revised with 3 materials. We aimed to compare the efficacy of these materials in pedicle augmentation and revision. Methods: One...
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What Are the Differences in Psychological Outcomes Between People Who Posted COVID-19-Related Content on Social Media and Those Who Did Not?

Zhang S, Zhang Y, Xue D, Zhang H, Chao M, Liu T

Objective During the lockdown of cities and home quarantine, media became the only way for people to conveniently get coronavirus disease-2019 (COVID-19)-related information. And media engagement was closely related to...
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Spinal Angiolipomas : Clinical Characteristics, Surgical Strategies and Prognosis

Zhang X, Dong S, Wang G, Zhang H, Wang JJ, Wang G

Objective : Angiolipomas are usually found in the subcutaneous tissue of the trunk and limbs. Spinal angiolipomas (SALs) are uncommon and have rarely been reported. We report a series of...
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Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome

Cheng ST, Chen WX, Deng HJ, He X, Zhang H, Tan M, Yu HB, Zhang ZZ, Ren JH, Yang ML, Zhang DP, Li ZH, Chen J

Background/Aims: Hepatitis B virus (HBV) hijacks host cell metabolism, especially host glutamine metabolism, to support its replication. Glutamate dehydrogenase 1 (GDH1), a mitochondrial enzyme crucial for glutamine metabolism, can interact...
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A Rapid and Convenient Method for in Vivo Fluorescent Imaging of Protoscolices of Echinococcus multilocularis

Yang T, Wang S, Zhang X, Xia J, Guo J, Hou J, Zhang H, Chen X, Wu X

Human and animal alveolar echinococcosis (AE) are important helminth infections endemic in wide areas of the Northern hemisphere. Monitoring Echinococcus multilocularis viability and spread using real-time fluorescent imaging in vivo...
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Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma

Zeng W, Liu F, Liu Y, Zhang Z, Hu H, Ning S, Zhang H, Chen X, Liao Z, Zhang Z

Background/Aims: Transmembrane 4 L six family member 1 (TM4SF1) is highly expressed and contributes to the progression of various malignancies. However, how it modulates hepatocellular carcinoma (HCC) progression and senescence...
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Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5–24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study

Wang L, Dai YJ, Cui Y, Zhang H, Jiang CH, Duan YJ, Zhao Y, Feng YF, Geng SM, Zhang ZH, Lu J, Zhang P, Zhao LW, Zhao H, Ma YT, Song CG, Zhang Y, Chen HS

Background and Purpose Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of...
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Lipidomic analysis of alcohol use disorder patients revealed the biomarkers for alcohol-related liver disease susceptibility

Wang D, Zhang H, Tang Y

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Lowest Instrumented Vertebra at L3 Versus L4 in Posterior Fusion for Moderate Lenke 5C Type Adolescent Idiopathic Scoliosis: A Case-Match Radiological Study

Li Z, Du Y, Zhao Y, Lin G, Zhang H, Li C, Ye X, Yang Y, Wang S, Zhang J

Objective: To compare the radiological outcomes in Lenke 5C type patients whose lowest instrumented vertebra (LIV) was L3 or L4 in a case-match study. Methods: We conducted a retrospective case-match study...
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Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43+ Cells via Cell-Cycle Regulation

Zeng J, Zhang H, Liu Y, Sun W, Yi D, Zhu L, Zhang Y, Pan X, Chen Y, Zhou Y, Bian G, Lai M, Zhou Q, Liu J, Chen B, Ma F

Background and Objectives: p21, an important member of the Cip/Kip family, is involved in inhibitory effects of RUNX1b overexpression during the early stage of human hematopoiesis. Methods and Results: We established...
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Laparoscopic left hepatectomy in swine: a safe and feasible technique

Zhang H, Liu T, Wang Y, Liu HF, Zhang JT, Wu YS, Lei L, Wang HB

A purely laparoscopic four-port approach was created for left hepatectomy in pigs. A polyethylene loop was placed on the left two hepatic lobes for traction and lift. Next, penetrating ligation...
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The Presence of EpCAM-/CD49f+ Cells in Breast Cancer Is Associated with a Poor Clinical Outcome

Ye F, Qiu Y, Li L, Yang L, Cheng F, Zhang H, Wei B, Zhang Z, Sun L, Bu H

PURPOSE: It is well established that breast cancer stem cells (BCSCs) play an essential role in tumor invasion for both local and distant metastasis. The aim of this study was...
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Sleep deprivation disrupts the lacrimal system and induces dry eye disease

Li S, Ning K, Zhou J, Guo Y, Zhang H, Zhu Y, Zhang L, Jia C, Chen Y, Sol Reinach P, Liu Z, Li W

Sleep deficiency is a common public health problem associated with many diseases, such as obesity and cardiovascular disease. In this study, we established a sleep deprivation (SD) mouse model using...
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Relations between Stress and Quality of Life among Women in Late Pregnancy: The Parallel Mediating Role of Depressive Symptoms and Sleep Quality

Zhang H, Zhang Q, Gao T, Kong Y, Qin Z, Hu Y, Cao R, Mei S

OBJECTIVE: This study aims to examine the parallel multiple mediators of depressive symptoms and sleep quality in the relations between stress and physical health-related quality of life (PHQOL)/mental health-related quality...
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Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma

Zhang H, Zhang J, Li C, Xu H, Dong R, Chen CC, Hua W

Objective : The function of B7H3, a member of the B7 family of proteins, in neuroblastoma (NB) remains poorly characterized. Here we examine the expression pattern of B7H3 in clinical...
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The Role of Neutrophil-to-Lymphocyte Ratio in Predicting Pathological Response for Resectable Non–Small Cell Lung Cancer Treated with Neoadjuvant Chemotherapy Combined with PD-1 Checkpoint Inhibitors

Sun X, Feng Y, Zhang B, Huang W, Zhao X, Zhang H, Yue D, Wang C

Purpose The aim of our study was to investigate the value of baseline and preoperative neutrophil-to-lymphocyte ratio (NLR) in predicting the pathological response and disease-free survival (DFS) of neoadjuvant chemotherapy alone...
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Automatic Detection and Classification of Rib Fractures on Thoracic CT Using Convolutional Neural Network: Accuracy and Feasibility

Zhou QQ, Wang J, Tang W, Hu ZC, Xia ZY, Li XS, Zhang R, Yin X, Zhang B, Zhang H

Objective: To evaluate the performance of a convolutional neural network (CNN) model that can automatically detect and classify rib fractures, and output structured reports from computed tomography (CT) images. Materials and...
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Global Research Trends of Exosomes in the Central Nervous System: A Bibliometric and Visualized Analysis

Zhuo Y, Ai K, He K, Wu B, Peng J, Xiang J, Zhang G, Jiao Z, Zhou R, Zhang H

Objective: Exosomes in the central nervous system (CNS) have become an attractive area of research with great value. However, few bibliometric analysis has been conducted. The study aimed to visualize...
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