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Isomangiferin, a Novel Potent Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor, Suppresses Breast Cancer Growth, Metastasis and Angiogenesis

Wang B, Shen J, Wang Z, Liu J, Ning Z, Hu M

PURPOSE: Vascular endothelial growth factor (VEGF) signal transduction mainly depends on its binding to VEGF receptor 2 (VEGFR-2). VEGF downstream signaling proteins mediate several of its effects in cancer progression,...
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6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Wang D, Jiang Y, Yang X, Wei Q, Wang H

Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have...
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Effect of Anti-vascular Endothelial Growth Factor Antibody on the Survival of Cultured Retinal Ganglion Cells

Lee JM, Bae HW, Lee SY, Seong GJ, Kim CY

PURPOSE: To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress. METHODS: We used real-time...
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Tea Flavonoids Induced Differentiation of Peripheral Blood-derived Mononuclear Cells into Peripheral Blood-derived Endothelial Progenitor Cells and Suppressed Intracellular Reactive Oxygen Species Level of Peripheral Blood-derived Endothelial Progenitor Cells

Widowati W, Wijaya L, Laksmitawati DR, Widyanto R, Erawijantari PP, Fauziah N, Bachtiar I, Sandra F

Endothelial dysfunction in atherosclerosis is associated with increasing oxidative stress that could be reversed by antioxidant. Therefore epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and catechin (C) of tea...
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Comparative Evaluation for Potential Differentiation of Endothelial Progenitor Cells and Mesenchymal Stem Cells into Endothelial-Like Cells

Sabry D, Noh O, Samir M

Understanding the mechanisms of vascular remodeling could lead to more effective treatments for ischemic conditions. We aimed to compare between the abilities of both human Wharton jelly derived mesenchymal stem...
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Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis

Park JH, Park GM, Kim JK

Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and...
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Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap

Jeong HS, Lee HK, Tark KC, Lew DH, Koh YW, Kim CH, Seo IS

The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming...
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Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review

Kang YH, Byun JH, Park BW

Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has...
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Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line

Flickinger I, Rutgen BC, Gerner W, Calice I, Tichy A, Saalmuller A, Kleiter M

To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1, cells...
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Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells

Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ

PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated...
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In Vitro and In Vivo Imaging of Prostate Cancer Angiogenesis Using Anti-Vascular Endothelial Growth Factor Receptor 2 Antibody-Conjugated Quantum Dot

Kwon H, Lee J, Song R, Hwang SI, Lee J, Kim YH, Lee HJ

OBJECTIVE: Authors aimed to determine the targeting ability of vascular endothelial growth factor receptor 2 (VEGFR2)-conjugated quantum dots (QDs) in vitro, and apply it for a xenograft prostate cancer mouse...
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Expression of Semaphorin 3A and Neuropilin 1 in Asthma

Shim EJ, Chun E, Kang HR, Cho SH, Min KU, Park HW

Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis...
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Photosensitivity Reactions to Vandetanib: Redevelopment after Sequential Treatment with Docetaxel

Son YM, Roh JY, Cho EK, Lee JR

Vandetanib (ZD6474, Zactima(TM)) is a novel, orally available inhibitor of different intracellular signaling pathways involved in tumor growth, progression, and angiogenesis, including vascular endothelial growth factor receptor-2, epidermal growth factor...
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Radiological Apoplexy and Its Correlation with Acute Clinical Presentation, Angiogenesis and Tumor Microvascular Density in Pituitary Adenomas

Lee JS, Park YS, Kwon JT, Nam TK, Lee TJ, Kim JK

OBJECTIVE: Pituitary apoplexy is life-threatening clinical syndrome caused by the rapid enlargement of a pituitary tumor due to hemorrhage and/or infarction. The pathogenesis of pituitary apoplexy is not completely understood....
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Inhibition of Lymphatic Endothelial Growth Factor Receptor in a Murine Model of Oral Squamous Cell Carcinoma

Kye JY, Park YW

  • KMID: 2136910
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2011 Jan;33(1):1-9.
PURPOSE: Tumor associated angiogenesis and/or lymphangiogenesis are known to be linked by VEGFR signaling pathways. These processes are regulated by several growth factors including VEGFR-2, VEGFR-3. E7080 is an orally...
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Visualization of Tumor Angiogenesis Using MR Imaging Contrast Agent Gd-DTPA-anti-VEGF Receptor 2 Antibody Conjugate in a Mouse Tumor Model

Jun HY, Yin HH, Kim SH, Park SH, Kim HS, Yoon KH

OBJECTIVE: To visualize tumor angiogenesis using the MRI contrast agent, Gd-DTPA-anti-VEGF receptor 2 antibody conjugate, with a 4.7-Tesla MRI instrument in a mouse model. MATERIALS AND METHODS: We designed a...
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Differences in Expression of VEGF-A, VEGFR-1, VEGFR-2 and Microvessel Density in Colorectal Cancer with Liver Metastasis

Jeong EH, Kim Y, Min BW, Lee KH, Kim HS, Lee JH

  • KMID: 2277533
  • Korean J Pathol.
  • 2010 Dec;44(6):571-580.
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients...
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Proliferation of endothelial progenitor cells by osteogenic differentiation of periosteal-derived cells

Kim JR, Song JH, Kim UK, Park BW, Hah YS, Kim JH, Kim DR, Cho YC, Sung IY, Byun JH

  • KMID: 1474220
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Aug;35(4):205-212.
PURPOSE : The purpose of this study was to examine the expression of various angiogenic factors during osteoblastic differentiation of periostealderived cells and the effects of osteogenic inductive medium of...
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Anti-Tumor Effects of Vascular Endothelial Growth Factor Inhibitor on Oral Squamous Cell Carcinoma Cell Lines

Han SJ, Lee JH

  • KMID: 2328428
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Apr;35(2):66-73.
Tumor angiogenesis is a process leading to formation of blood vessels within tumors and is crucial for maintaining a supply of oxygen and nutrients to support tumor growth and...
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Targeting Receptor Tyrosine Kinase on Endothelial Cells in an Orthotopic Tumor Model of Oral Squamous Cell Carcinorma

Park YW, Kim SH

  • KMID: 2328427
  • J Korean Assoc Oral Maxillofac Surg.
  • 2009 Apr;35(2):55-65.
PURPOSE: We determined the therapeutic effects of blockade of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases on the growth of oral squamous cell carcinoma...
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