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Growth in Infants with Cow's Milk Protein Allergy Fed an Amino AcidBased Formula

Vandenplas Y, Dupont C, Eigenmann P, Heine RG, Høst A, Järvi A, Kuitunen M, Mukherjee R, Ribes-Koninckx C, Szajewska H, Berg Av, Zhao ZY, on behalf of the Mosaic Study Investigator Group

Purpose: The present study assessed the role of an amino acid-based formula (AAF) in the growth of infants with cow's milk protein allergy (CMPA). Methods: Non-breastfed, term infants aged 0–6 months...
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Retrospective and Prospective Determination of the Cow's MilkRelated Symptom Score (CoMiSS™) Values in Symptomatic Infants

Kozłowska-Jalowska A, Horvath A, Vandenplas Y, Szajewska H

Purpose: The Cow's Milk-related Symptom Score (CoMiSS™) was developed as an awareness tool for evaluating cow's milk-related symptoms in otherwise healthy children. Using a convenience sample of participants, this cross-sectional...
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Probiotics in the Prevention and Treatment of Necrotizing Enterocolitis

Seghesio E, Geyter CD, Vandenplas Y

Necrotizing enterocolitis (NEC) is a disease with high morbidity and mortality that occurs mainly in premature born infants. The pathophysiologic mechanisms indicate that gastrointestinal dysbiosis is a major risk factor....
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Diagnosis and Management of Ménétrier Disease in Children: A Case Series Review

Krikilion J, Levy EI, Vandenplas Y

Purpose: Ménétrier disease (MD) was first described in 1888, and 50 cases have been reported until now. We aimed to discuss the etiology, diagnostics, and management of MD in children. Methods:...
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Real Time Versus Photographic Assessment of Stool Consistency Using the Brussels Infant and Toddler Stool Scale: Are They Telling Us the Same?

Aman BA, Levy EI, Hofman B, Vandenplas Y, Huysentruyt K

Purpose: Digital communication is becoming increasingly important in clinical practice and research. The finding that stool consistency can be evaluated similarly using either “in vivo” or photographic material by health...
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Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis

Kluijfhout S, Trieu TV, Vandenplas Y

Purpose: Some probiotic strains reduce the duration of acute diarrhea. Because of strain and product specificity, each product needs to be supported by clinical data. This study aimed to test...
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Effect of Supplementation of Zinc, Glutamine, Fiber, and Prebiotics in Presumed Healthy Indonesian Children Aged 1–3 Years

Kadim M, Hegar B, Bardosono S, Timan IS, Gunardi H, Prasetyo D, Firmansyah A, Vandenplas Y

Purpose: Impaired intestinal mucosal integrity may affect the gastrointestinal function, especially in relation to nutrition, absorption, and barrier function. The purpose of this study was to measure the prevalence of...
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Cow's Milk-Related Symptom Score in Presumed Healthy Polish Infants Aged 0–6 Months

Bigorajska K, Filipiak Z, Winiarska , Adamiec A, Trent B, Vandenplas Y, Ruszczyński M, Szajewska

PURPOSE: The Cow's Milk-related Symptom Score (CoMiSSâ„¢), which considers crying, regurgitation, stools, skin and respiratory symptoms, was developed as an awareness tool for evaluating cow's milk-related symptoms. The scoring ranges...
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Effectiveness and Tolerance of a Locust Bean Gum-Thickened Formula: A Real-Life Study

Tounian P, Meunier L, Speijers G, Oozeer R, Vandenplas Y

Purpose: Thickened infant formulas reduce regurgitation frequency and volume. Because the digestive tolerance of locust bean gum-containing formulas is controversial, the effectiveness and tolerance of a locust bean gum-thickened formula...
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The Gastroesophageal Reflux Disease Questionnaire in Adolescents: What Is the Best Cutoff Score?

Artanti D, Hegar B, Kaswandani N, Soedjatmiko , Prayitno A, Devaera Y, Vandenplas Y

BACKGROUND: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL). METHODS:...
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The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition

Hegar B, Wibowo Y, Basrowi RW, Ranuh RG, Sudarmo SM, Munasir Z, Atthiyah A, Widodo AD, Supriatmo , Kadim M, Suryawan A, Diana NR, Manoppo C, Vandenplas Y

Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2′-fucosyllactose (2′-FL) and...
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A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants

Vandenplas Y, Munasir Z, Hegar B, Kumarawati D, Suryawan A, Kadim M, Djais JT, Basrowi RW, Krisnamurti D

The World Health Organization recommends that infants should be exclusively breastfed for the first 6 months of life to provide optimal nutrition in this critical period of life. After this,...
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The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study

Benninga M, MENA Infant Constipation Study Group, Vandenplas Y

PURPOSE: To compare the effectiveness of the magnesium (Mg)-enriched formula vs. control formula in constipated infants. METHODS: An open-label, interventional, and the comparator-controlled study was conducted to evaluate the effectiveness of...
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Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family

Vandenplas Y, Hauser B, Salvatore

Functional gastrointestinal disorders (FGIDs) such as infantile colic, constipation and colic occur in almost half of the infants. The aim of this paper is to provide a critical and updated...
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Intestinal Spirochetosis: A Case Series and Review of the Literature

Lemmens R, Devreker T, Hauser B, Degreef E, Goossens A, Vandenplas Y

A clinical suspicion of intestinal spirochetosis is required when patients have long lasting complaints of abdominal pain, diarrhea, rectal bleeding, weight loss, and nausea. An endoscopy with biopsies needs to...
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Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice

Gonzalez Ayerbe JI, Hauser B, Salvatore , Vandenplas Y

The diagnosis and management of gastro-esophageal reflux (GER) and GER disease (GERD) in infants and children remains a challenge. Published guidelines and position papers, along with Embase, MEDLINE, and the...
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Breastfeeding Knowledge, Attitude, and Practice among White-Collar and Blue-Collar Workers in Indonesia

Basrowi RW, Sulistomo , Adi NP, Widyahening IS, Vandenplas Y

BACKGROUND: Working status is identified as a major risk factor of poor breastfeeding practices among workers. This study aimed to evaluate the knowledge, attitude, and factors associated with breastfeeding practice...
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Lactobacillus reuteri DSM 17938 Improves Feeding Intolerance in Preterm Infants

Kaban RK, Wardhana , Hegar B, Rohsiswatmo R, Handryastuti S, Amelia N, Muktiarti , Indrio F, Vandenplas Y

PURPOSE: Feeding tolerance is extremely important in preterm infants. This study aimed to evaluate whether preterm infants receiving Lactobacillus reuteri DSM 17938 would develop fewer symptoms of feeding intolerance. Secondary...
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Physicians' Understanding of Nutritional Factors Determining Brain Development and Cognition in the Middle East and Africa

Vandenplas Y, Rakhecha A, Edris A, Shaaban B, Tawfik E, Bashiri FA, AlAql F, Alsabea H, Haddad J, El Barbary M, Salah M, Abouelyazid M, Kumar M, Alsaad S

PURPOSE: Proper nutrition is essential for brain development during infancy, contributing to the continued development of cognitive, motor, and socio-emotional skills throughout life. Considering the insufficient published data in the...
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An Electronic Questionnaire Survey Evaluating the Perceived Prevalence and Practices of Lactose Intolerance in 1 to 5 Year Old Children in South East Asia

Tan ML, Muhardi L, Osatakul S, Hegar B, Vandenplas Y, Ludwig T, Bindels J, Van der Beek EM, Quak SH

PURPOSE: Lactose intolerance (LI) is perceived to be frequent in Asia and has been reported to have considerable impact on dietary intake, nutritional status and the quality of life. We...
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