Korean J Pediatr.  2019 May;62(5):149-154. 10.3345/kjp.2018.07276.

A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants

  • 1KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussel, Belgium. Yvan.Vandenplas@uzbrussel.be
  • 2Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • 3Department of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, Indonesia.
  • 4Department of Child Health, Medical School, Unviersity of Airlangga, Surabaya, Indonesia.
  • 5Department of Child Health, Medical School, University of Padjadjaran, Bandung, Indonesia.
  • 6Nestle Nutrition Institute, Jakarta, Indonesia.


The World Health Organization recommends that infants should be exclusively breastfed for the first 6 months of life to provide optimal nutrition in this critical period of life. After this, infants should receive nutritionally adequate and safe complementary foods while breastfeeding continues for up to 2 years of age or beyond. For nonbreastfed infants, infant formula is an available option to provide the nutrition needed. Infant formula is usually prepared from industrially modified cow's milk and processed to adjust for the nutritional needs of infants. However, cow's milk is one of the most common causes of food allergy, affecting 2%-5% of all formula-fed infants during their first year of life. One strategy to prevent cow's milk allergy in nonbreastfed infants is the use of partially hydrolyzed formula (pHF) in high-risk infants, which are infants born in families with atopic disease. However, based on an epidemiological study, approximately half of the infants who develop allergy are not part of the at-risk group. This is because the non-at-risk group is significantly larger than the at-risk group and the non-at-risk infants have approximately 15% risk of developing allergies. This study aimed to evaluate the effects of partially hydrolyzed whey formula (pHF-W) in nonbreastfed infants and determine whether pHF-W can prevent atopic disease in high-risk infants and can be used as routine starter formula regardless of the allergy risk status.


Partial hydrolysate; Cow's milk protein allergy; Breastfeeding; Formula feeding; Hydrolysate; Infant feeding

MeSH Terms

Breast Feeding
Critical Period (Psychology)
Epidemiologic Studies
Food Hypersensitivity
Infant Formula*
Milk Hypersensitivity
World Health Organization
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