Pediatr Gastroenterol Hepatol Nutr.  2019 Jul;22(4):330-340. 10.5223/pghn.2019.22.4.330.

The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition

Affiliations
  • 1Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
  • 2Nestle Nutrition Institute, Indonesia.
  • 3Soetomo Hospital, Faculty of Medicine University Airlangga, Surabaya, Indonesia.
  • 4Harapan Kita Hospital, Jakarta, Indonesia.
  • 5Adam Malik Hospital, Sumatera Utara, Indonesia.
  • 6Kariadi Hospital, Semarang, Indonesia.
  • 7Kandou Hospital, Manado, Indonesia.
  • 8KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium. yvan.vandenplas@uzbrussel.be

Abstract

Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2"²-fucosyllactose (2"²-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2"²-FL and LNnT is a promising innovation for infant nutrition.

Keyword

Human milk; Oligosaccharide; 2′-fucosyllactose; Lacto-N-neotetraose; Infant; Breast feeding

MeSH Terms

Breast Feeding
Epithelial Cells
Gastrointestinal Microbiome
Genetic Background
Health Maintenance Organizations
Humans*
Immune System
Infant Formula
Infant*
Insurance Benefits
Lactose
Milk, Human*
Mothers
Oligosaccharides*
Lactose
Oligosaccharides
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