- Role of Periostin in Hepatocellular Carcinoma: The Importance of Tumor Microenvironment
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Lee JI
- KMID: 2412090
- Gut Liver.
- 2016 Nov;10(6):871-872.
- doi: 10.5009/gnl16429
No abstract available. -
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- Interactions between Immune Cells and Tumor Cells
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Cho SW
- KMID: 1845379
- J Korean Thyroid Assoc.
- 2013 Nov;6(2):96-100.
- doi: 10.11106/jkta.2013.6.2.96
Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune... -
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- Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
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Jeong HM, Cho SW, Park SI
- KMID: 2373065
- Endocrinol Metab.
- 2016 Dec;31(4):485-492.
- doi: 10.3803/EnM.2016.31.4.485
The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and... -
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- Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy
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Arab S, Hadjati J
- KMID: 2455933
- Immune Netw.
- 2019 Aug;19(4):e23.
- doi: 10.4110/in.2019.19.e23
Immunotherapy has been introduced into cancer treatment methods, but different problems have restricted the efficacy of these protocols in clinical trials such as the presence of various immunomodulatory factors in... -
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- Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy
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Kim JH, Kim BS, Lee SK
- KMID: 2471044
- Immune Netw.
- 2020 Feb;20(1):e4.
- doi: 10.4110/in.2020.20.e4
Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies... -
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- IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment
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Choi JN, Sun EG, Cho SH
- KMID: 2432253
- Chonnam Med J.
- 2019 Jan;55(1):31-39.
- doi: 10.4068/cmj.2019.55.1.31
Myeloid derived suppressor cells (MDSCs) are a heterogenous population of immature cells that play a critical role in tumor associated immune suppression. In tumor conditions, the population of MDSCs increases.... -
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- IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
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Kuen DS, Kim BS, Chung Y
- KMID: 2471046
- Immune Netw.
- 2020 Feb;20(1):e6.
- doi: 10.4110/in.2020.20.e6
IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is... -
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- Update on immune checkpoint inhibitors in gynecological cancers
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Heong V, Ngoi N, Tan DS
- KMID: 2413459
- J Gynecol Oncol.
- 2017 Mar;28(2):e20.
- doi: 10.3802/jgo.2017.28.e20
In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy... -
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- Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)
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Nam S, Lee A, Lim J, Lim JS
- KMID: 2432068
- Biomol Ther.
- 2019 Jan;27(1):63-70.
- doi: 10.4062/biomolther.2018.201
Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as... -
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- Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy
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Lee S, Kim DH, Oh SY, Kim SY, Koh MS, Lee JH, Lee S, Kim SH, Kwak JY, Pak MG, Ju MH, Kim HJ, Jeong JS
- KMID: 2371657
- Korean J Intern Med.
- 2017 Mar;32(2):335-344.
- doi: 10.3904/kjim.2015.161
BACKGROUND/AIMS: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) is a regulator of T lymphocyte in the microenvironment... -
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- Lesionalized Therapy beyond Personalized Therapy in Cancer Management
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Chung JK, Kim MJ, Youn H
- KMID: 2129621
- J Korean Med Sci.
- 2014 Oct;29(10):1331-1332.
- doi: 10.3346/jkms.2014.29.10.1331
No abstract available. -
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- Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments
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Lee IJ, Lee EJ, Park H, Kim W, Ha SJ, Shin YK, Seong J
- KMID: 2454351
- Cancer Res Treat.
- 2016 Apr;48(2):727-737.
- doi: 10.4143/crt.2014.350
PURPOSE: This study was conducted to evaluate the biological features of murine hepatocarcinoma according to different tumor microenvironmental models and to determine the change in molecular and immunologic responses after... -
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- The effects of nutrient depleted microenvironments and delta-like 1 homologue (DLK1) on apoptosis in neuroblastoma
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Kim Y
- KMID: 2313480
- Nutr Res Pract.
- 2010 Dec;4(6):455-461.
The tumor microenvironment, particularly sufficient nutrition and oxygen supply, is important for tumor cell survival. Nutrition deprivation causes cancer cell death. Since apoptosis is a major mechanism of neuronal loss,... -
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- Cellular immunotherapy using dendritic cells against multiple myeloma
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Nguyen-Pham TN, Lee YK, Lee HJ, Kim MH, Yang DH, Kim HJ, Lee JJ
- KMID: 2251967
- Korean J Hematol.
- 2012 Mar;47(1):17-27.
- doi: 10.5045/kjh.2012.47.1.17
Cellular therapy with dendritic cells (DCs) is emerging as a useful immunotherapeutic tool to treat multiple myeloma (MM). DC-based idiotype vaccination was recently suggested to induce idiotype-specific immune responses in... -
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- Recently Developed Therapeutic Agents for B-cell Non-Hodgkin Lymphoma
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Park BB
- KMID: 2082581
- Korean J Med.
- 2015 Mar;88(3):247-251.
- doi: 10.3904/kjm.2015.88.3.247
While most B-cell lymphomas are cured by chemotherapy, in recent years research interest has focused on the development of monoclonal antibodies and small molecules targeting membrane proteins, components of signaling... -
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- Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
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Cho J, Kang MS, Kim KM
- KMID: 2372546
- J Gastric Cancer.
- 2016 Mar;16(1):1-7.
- doi: 10.5230/jgc.2016.16.1.1
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has... -
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- High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea
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Jung BK, Song H, Kim MJ, Cho J, Shin EH, Chai JY
- KMID: 2164019
- Korean J Parasitol.
- 2016 Apr;54(2):201-204.
- doi: 10.3347/kjp.2016.54.2.201
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has... -
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- Diagnostic Significance of pH-Responsive Gd³âº-Based Tâ‚ MR Contrast Agents
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Bhuniya S, Hong KS
- KMID: 2442229
- Investig Magn Reson Imaging.
- 2019 Mar;23(1):17-25.
- doi: 10.13104/imri.2019.23.1.17
We discuss recent advances in Gd-based Tâ‚-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two... -
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- DNA methylation: an epigenetic mark of cellular memory
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Kim M, Costello J
- KMID: 2382713
- Exp Mol Med.
- 2017 Apr;49(4):e322.
- doi: 10.1038/emm.2017.10
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may... -
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- Convergence of Cancer Metabolism and Immunity: an Overview
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Van Dang C, Kim JW
- KMID: 2400809
- Biomol Ther.
- 2018 Jan;26(1):4-9.
- doi: 10.4062/biomolther.2017.194
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence... -
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