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Heterologous corneal endothelial cell transplantation: human corneal endothelial cell transplantation in Lewis rats

Tchah H

A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea,...
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Opening the era of in vivo xenotransplantation model for hematopoietic stem cell transplantation

Lee JW, Oh IH

  • KMID: 1927474
  • Korean J Med.
  • 2003 Sep;65(3):269-271.
No abstract available.
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The Role of Macrophages in Transplant Rejection

Yeom HJ, Ahn C, Yang J

Macrophage accumulation has been recognized as a feature of allograft rejection, however, the role of macrophages in rejection remains underappreciated. Macrophages are present within graft tissues throughout the lifespan of...
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Macrophages in xenotransplantation

Kim JY

Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed...
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Current Status of Solid Organ Xenotransplantation

Yun IJ

Solid organ xenotransplantation using transgenic pig organs is proposed as an alternative method for allo-transplantation. To accomplish this, immunologic and non-immunologic barriers for xenotransplantation should be overcome, and experiments on...
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Study on the Immunologic Mechanism in the Xenogenic Transplantation

Han DJ, Lee HM, Kim SC, We YM, Kang HY, Kim JY, Yu ES, Park SH

  • KMID: 1548227
  • Korean J Immunol.
  • 1997 Jun;19(2):277-288.
Organ transplantation has become a' widely accepted treatment modality for end-stage organ disease. The shortage of allogenic donors for organ transplantation has brought about the necessity of xenotransplantation as an...
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Ovarian tissue cryopreservation and transplantation

Park KH, Lee BS, Chung DJ

  • KMID: 2272986
  • Korean J Obstet Gynecol.
  • 2006 Dec;49(12):2473-2478.
This review focuses on the current options for fertility preservation in patients with high risk of premature ovarian failure. Available cryopreservation options include embryo cryopreservation, oocyte cryopreservation, and ovarian tissue...
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Pharmacokinetics and cytotoxic effect of selenium compounds in rodent cancer xenograft model for therapy experiment

Hwang JY

No abstract available.
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The Past, Present, and Future of Xenotransplantation

Ahn C, Kim JY, Lee BC, Kang SK, Lee JR, Hwang WS

No abstract available.
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Experimental Model of Cardiac Xenograft , Mouse Heart to Rat

Kim BI, Son ST, Shin SH, Jung WS, Kim H, Kim YH, Kang JH, Jee HO, Lee CB, Suh JK

  • KMID: 2289024
  • Korean J Thorac Cardiovasc Surg.
  • 1999 Jan;32(1):1-4.
BACKGROUND: The transplantation of organs between phylogenetically disparate or harmonious species has invariably failed due to the occurrence of hyperacute rejection or accerelated acute rejection. But concordant cardiac xenograft offer...
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Xenograft Failure of Pulmonary Valved Conduit Cross-linked with Glutaraldehyde or Not Cross-linked in a Pig to Goat Implantation Model

Kim DJ, Kim YJ, Kim WH, Kim SH

BACKGROUND: Biologic valved grafts are important in cardiac surgery, and although several types of graft are currently available, most commercial xenografts tend to cause early disfiguration due to intimal proliferation...
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Transplantation Immunology from the Historical Perspective

Park CG

Transplantation would be the only way to cure the end-stage organ failure involving heart, lung, liver, kidney and pancreas. The replacement of the parts of the body damaged to lose...
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The Role of Cyclosporine and Mycophenolate in an Orthotopic Porcine-to-Rat Corneal Xenotransplantation

Lee HI, Kim MK, Oh JY, Ko JH, Lee HJ, Wee WR, Lee JH

We performed this study to investigate the feature of rejection in porcine-to-rat corneal orthotopic transplantation and to evaluate the effect of cyclosporine and mycophenolate on the xeno-rejection. Orthotopic corneal transplantation...
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Islet Encapsulation Using Chondrocyte

Lee JI, Kim JY, Lee JG, Kim YS

Diabetes mellitus is one of the leading metabolic diseases that cause an increasing rate of mortality and morbidity. Recently, rather than the current drug treatment, pancreatic islet transplantation has been...
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Implications of Calcineurin/NFAT Inhibitors' Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation

Kim YH, Lee WW, Park CG

Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506) are broadly used in organ transplantations as immune suppressants. As the calcineurin/NFAT signaling pathway has been identified as critical pathway in the...
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The Fetal Sheep: A Unique Model System for Assessing the Full Differentiative Potential of Human Stem Cells

Porada GA, Porada C, Zanjani ED

The naturally occurring stem cell migratory patterns, the availability of expanding homing and engraftment sites, and the presence of tissue/organ-specific signals in the developing mammalian fetus provide the ideal setting...
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Current Strategies for Successful Islet Xenotransplantation

Kim H, Yang J, Ahn C

Diabetes mellitus is increasing all over the world and is a serious health problem. Pancreatic islet transplantation is promising treatment for diabetes mellitus, but an imbalance between deceased pancreas donors...
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The Study of Characteristics of Acellular Porcine Cornea Using Freezing-Thawing-Centrifugation

Lee SH, Chun YS, Kim JC

PURPOSE: To develop a new decellularization technique of porcine cornea using freezing-thawing-centrifugation (FTC) and to examine the characteristics of acellular porcine cornea (APC) for xenograft material. METHODS: Two-hundred micrometer thickness porcine...
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Current Status and Future Perspectives of Xenotransplantation and Stem Cell Research in Transplantation Field

Park CG, Kim JS, Kim YH

The severe shortage of human organ donors is one of the biggest problems with organ transplantation. The solution for this problem would be development of artificial organs or mechanical devices,...
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The Effect of Intravenous Immunoglobulin on Hyperacute and Acclerated Rejection in Heart Transplantation of the Rat

Kim SC, Han DJ, Kim TH, We YM, Cho KM

  • KMID: 2198966
  • J Korean Soc Transplant.
  • 2001 Dec;15(2):125-129.
Hyperacute or acute accelerated rejection caused by preformed antibody in sensitized patients resulted in increased waiting period and complicated posttransplant hospital course. Intravenous immunoglobulin (IVIG) has known to have anti...
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