Korean J Thorac Cardiovasc Surg.  1999 Jan;32(1):1-4.

Experimental Model of Cardiac Xenograft , Mouse Heart to Rat

• Kim BI
• Son ST
• Shin SH
• Jung WS
• Kim H
• Kim YH
• Kang JH
• Jee HO
• Lee CB
• Suh JK

Abstract

BACKGROUND: The transplantation of organs between phylogenetically disparate or harmonious species has invariably failed due to the occurrence of hyperacute rejection or accerelated acute rejection. But concordant cardiac xenograft offer us an opportunity to study xenotransplantation in the absence of hyperacute rejection. Current therapeutics for the prolongation of survival of rodent concordant xenotransplantation are not ideal with many regimens having a high mortality rate. Cyclosporine A & Mycophenolate Mofetil are new immunosuppresive agent which has been shown to be effective at prolonging survival of allograft, as purine synthesis inhibitor. MATERIAL AND METHOD: We used white mongrel rats as recipient and mice as donor, divided 4 groups(n=6), control group(Group 1) has no medication or pretreatment, Group 2 has splenectomy as pretreatment 7~10 days before transplantation, Group 3 has Cyclosporine A treatment group, Group 4 has combined treatment of Cyclosporine A & Mycophenolate Mofetil(RS 61443). We compared survival time. RESULT: We can't find significant difference of survival time between each groups.
CONCLUSION
We concluded that rejection of cardiac xenograft was different from rejection of allograft, and new immunossuppresive Agent(Mycophenolate Mofetil, Cyclosporine A) was not effective for prolongation of survival time after cardiac xenograft.

Keyword

Transplantation; heterologous; Immunosuppression

MeSH Terms

Allografts
Animals
Cyclosporine
Heart*
Heterografts*
Humans
Immunosuppression
Mice*
Models, Theoretical*
Mortality
Rats*
Rodentia
Splenectomy
Tissue Donors
Transplantation
Transplantation, Heterologous
Cyclosporine