Yeungnam Univ J Med.  1987 Aug;4(1):81-87. 10.12701/yujm.1987.4.1.81.

Study of the Experimental Dermatophyte Infection in Animals

• Choi JS
• Hwang KY
• Kim KH
• Kim SK
• Chung JK
• Suh SB

• KMID: 2373919
• DOI: http://doi.org/10.12701/yujm.1987.4.1.81

Abstract

Experimental dermatophyte infections are essential for studying dermatophytosis. Induction of standard infections depends on control of three factors-spore dose, scarification, and species of the experimental animals. The authors evaluated the three factors in the experimental infection models, which were inoculated with quantitated spore solution of N.gypsea "+" and A. benhomiae "+" in rabbit, guinea pig, rat, and mouse. The results were as follows. 1. Infection was correlated with concentration of inoculums. 2. In traumatization method, abrasion with knife was the most effective for inoculation, followed by pricking, epilation, and shaving of hair in decreasing order. 3. Rabbit and guinea pig were more susceptible to dermatophyte infection rather than the rat and mouse. However, the mouse was not infected at all. 4. Guinea pig was the proper animal model for experimental dermatophytosis in susceptibility, degree of clinical response, and duration of the infection. 5. A.benhamiae "+" showed more severe inflammation and shorter course the N.gypsea "+".

MeSH Terms

Animals*
Arthrodermataceae*
Guinea Pigs
Hair
Hair Removal
Inflammation
Methods
Mice
Models, Animal
Rats
Spores
Tinea