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Retraction and Republication: A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies

Chung I, Oh J, Lee S, Jang IJ, Lee Y, Chung JY

The retraction has been agreed upon due to critical typographical errors throughout the contents from accidents at the manuscript editing step.
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Comparison of various estimation methods for the parameters of Michaelis-Menten equation based on in vitro elimination kinetic simulation data

Cho YS, Lim HS

The Michaelis-Menten equation is one of the best-known models describing the enzyme kinetics of in vitro drug elimination experiments, and takes a form of equation relating reaction rate (V) to...
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Quantitative analysis of acetylsalicylic acid in human blood using volumetric absorptive microsampling

Kim Y, Jeon JY, Han SH, Ha N, Jang K, Kim MG

Volumetric absorptive microsampling (VAMS) is a novel sampling technique that allows for the collection of an accurate volume of blood by dipping a microsampler tip. The purpose of this study...
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Population pharmacokinetic analysis of metformin administered as fixed-dose combination in Korean healthy adults

Choi S, Jeon S, Han S

Metformin, an oral antihyperglycemic agent, is widely used as the first-line pharmacotherapy for type 2 diabetes mellitus (T2DM). It has been in use for several decades as numerous different formulations....
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Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects

Hwang I, Park SI, Lee S, Lee B, Yu KS, Jeon JY, Kim MG

This study aimed to compare the pharmacokinetics of fixed-dose combination (FDC) tablet of rosuvastatin 20 mg/ezetimibe 10 mg with that of concurrent administration of individual rosuvastatin 20 mg tablet and...
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Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)

Kim H, Han S, Cho YS, Yoon SK, Bae KS

Noncompartmental analysis (NCA) is a primary analytical approach for pharmacokinetic studies, and its parameters act as decision criteria in bioequivalent studies. Currently, NCA is usually carried out by commercial softwares...
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A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies

Chung I, Oh J, Lee S, Jang IJ, Lee Y, Chung JY

Because bioequivalence studies are performed using a crossover design, information on the intra-subject coefficient of variation (intra-CV) for pharmacokinetic measures is needed when determining the sample size. However, calculated intra-CVs...
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Understanding the pharmacokinetics of prodrug and metabolite

Cho S, Yoon YR

This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In...
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