- The Role of Transient Receptor Potential Channel in Pain
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Jung SJ
- KMID: 2168188
- Hanyang Med Rev.
- 2011 May;31(2):116-122.
- doi: 10.7599/hmr.2011.31.2.116
Transient receptor potential (TRP) channels, a large family of receptor channel proteins, initially attracted researchers in the pain field as key molecules in nociception, but later they became known as... -
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- Immunohistochemical Study on the Distribution of Canonical Transient Receptor Potential Channels in Rat Cerebellum
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Chung YH, Ahn HS
- KMID: 1481581
- Korean J Phys Anthropol.
- 2008 Mar;21(1):69-75.
Channels formed by the transient receptor potential (TRP) family of proteins have a variety of physiological functions. In the present study, we examined the localization of canonical transient receptor potential... -
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- Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases
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Xiao X, Liu HX, Shen K, Cao W, Li XQ
- KMID: 2389378
- Biomol Ther.
- 2017 Sep;25(5):471-481.
- doi: 10.4062/biomolther.2016.096
The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4,... -
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- Identification of phospholipase C β downstream effect on transient receptor potential canonical 1/4, transient receptor potential canonical 1/5 channels
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Ko J, Myeong J, Kwak M, Jeon JH, So I
- KMID: 2455812
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):357-366.
- doi: 10.4196/kjpp.2019.23.5.357
Gα(q)-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate (PI(4,5)P₂) depletion. When PI(4,5)P₂... -
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- Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
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Saito M
- KMID: 2271146
- Korean J Obes.
- 2015 Mar;24(1):1-8.
- doi: 10.7570/kjo.2015.24.1.1
Brown adipose tissue (BAT) is a site of sympathetically activated non-shivering thermognenesis during cold exposure and after spontaneous hyperphagia, thereby involving in the autonomic regulation of energy balance and body... -
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- Skin Barrier and Calcium
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Lee SE, Lee SH
- KMID: 2419166
- Ann Dermatol.
- 2018 Jun;30(3):265-275.
- doi: 10.5021/ad.2018.30.3.265
Epidermal barrier formation and the maintenance of barrier homeostasis are essential to protect us from the external environments and organisms. Moreover, impaired keratinocytes differentiation and dysfunctional skin barrier can be... -
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- Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
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Saito M
- KMID: 2280738
- Diabetes Metab J.
- 2013 Feb;37(1):22-29.
- doi: 10.4093/dmj.2013.37.1.22
Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat.... -
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- Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
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Noh J, Chung JM
- KMID: 2463713
- Exp Neurobiol.
- 2019 Oct;28(5):578-592.
- doi: 10.5607/en.2019.28.5.578
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state... -
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- Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
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Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I
- KMID: 2466574
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):101-110.
- doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With... -
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- Expression of transient receptor potential channels in the ependymal cells of the developing rat brain
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Jo KD, Lee KS, Lee WT, Hur MS, Kim HJ
- KMID: 2046759
- Anat Cell Biol.
- 2013 Mar;46(1):68-78.
- doi: 10.5115/acb.2013.46.1.68
Cerebrospinal fluid (CSF) plays an important role in providing brain tissue with a stable internal environment as well as in absorbing mechanical and thermal stresses. From its initial composition, derived... -
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- Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
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Nishida M, Tanaka T, Mangmool S, Nishiyama , Nishimura
- KMID: 2470805
- J Lipid Atheroscler.
- 2020 Jan;9(1):124-139.
- doi: 10.12997/jla.2020.9.1.124
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully... -
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- Magnesium Metabolism
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Seo JW, Park TJ
- KMID: 2134810
- Electrolyte Blood Press.
- 2008 Dec;6(2):86-95.
- doi: 10.5049/EBP.2008.6.2.86
Magnesium is the second most common intracellular divalent cation. Magnesium balance in the body is controlled by a dynamic interplay among intestinal absorption, exchange with bone, and renal excretion. Intestinal... -
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- The role of calmodulin in regulating calcium-permeable PKD2L1 channel activity
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Park EY, Baik JY, Kwak M, So I
- KMID: 2443609
- Korean J Physiol Pharmacol.
- 2019 May;23(3):219-227.
- doi: 10.4196/kjpp.2019.23.3.219
Polycystic kidney disease 2-like-1 (PKD2L1), polycystin-L or transient receptor potential polycystin 3 (TRPP3) is a TRP superfamily member. It is a calcium-permeable non-selective cation channel that regulates intracellular calcium concentration... -
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- 'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?
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Atkinson N, Reynolds D, Travis SP
- KMID: 2174468
- Intest Res.
- 2015 Jul;13(3):227-232.
- doi: 10.5217/ir.2015.13.3.227
Proton pump inhibitors (PPIs) are widely used though an association with hypomagnesaemia and hypocalcaemia has only been described since 2006. Patients typically present after years of stable dosing with musculoskeletal,... -
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- TRPC3 cation channel plays an important role in proliferation and differentiation of skeletal muscle myoblasts
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Woo JS, Cho CH, Kim DH, Lee EH
- KMID: 983954
- Exp Mol Med.
- 2010 Sep;42(9):614-627.
- doi: 10.3858/emm.2010.42.9.061
During membrane depolarization associated with skeletal excitation-contraction (EC) coupling, dihydropyridine receptor [DHPR, a L-type Ca2+ channel in the transverse (t)-tubule membrane] undergoes conformational changes that are transmitted to ryanodine receptor... -
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- Prediction of itching diagnostic marker through RNA sequencing of contact hypersensitivity and skin scratching stimulation mice models
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Kim YW, Zhou T, Ko EA, Kim S, Lee D, Seo Y, Kwon N, Choi T, Lim H, Cho S, Bae G, Hwang Y, Kim D, Park H, Lee M, Jang E, Choi J, Bae H, Lim I, Bang H, Ko JH
- KMID: 2438089
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):151-159.
- doi: 10.4196/kjpp.2019.23.2.151
Pruritus (itching) is classically defined as an unpleasant cutaneous sensation that leads to scratching behavior. Although the scientific criteria of classification for pruritic diseases are not clear, it can be... -
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