Hanyang Med Rev.  2011 May;31(2):116-122. 10.7599/hmr.2011.31.2.116.

The Role of Transient Receptor Potential Channel in Pain

• Jung SJ

• KMID: 2168188
• DOI: http://doi.org/10.7599/hmr.2011.31.2.116

Abstract

Transient receptor potential (TRP) channels, a large family of receptor channel proteins, initially attracted researchers in the pain field as key molecules in nociception, but later they became known as more general transducer molecules for various physical stresses. In this review, I will discuss their roles in thermal and mechanical sensation, and then consider their contribution to physiological pain.

Keyword

Pain; Transient receptor potential channels; Thermo-sensor; Mechano-sensor; Transducer

MeSH Terms

Humans
Nociception
Proteins
Sensation
Transducers
Transient Receptor Potential Channels
Proteins
Transient Receptor Potential Channels

Figure

• 

  Fig. 1 Temperature thresholds, chemical agonists, and tissue distribution of six temperature-sensitive TRP channels. NADA, N-arachidonoyl-dopamine; 2-APB, 2-aminoethoxydiphenyl borate; DPBA, diphenylboronic anhydride; 4α-PDD, 4α-phorbol 12,13-didecanoate; PMA, phorbol 12-myristate 13-acetate; PtdIns (4,5)P2, phosphatidylinositol 4,5-bisphosphate; HNE, 4-hydroxynonenal; THC, tetrahydrocannabinol.30

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