- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique
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Kim HJ, Jeong J, Park S, Jin YW, Lee SS, Lee SB, Choi D
- KMID: 2412193
- Gut Liver.
- 2017 Mar;11(2):261-269.
- doi: 10.5009/gnl15389
BACKGROUND/AIMS: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects... -
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- Role of the epithelial-mesenchymal transition and its effects on embryonic stem cells
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Kim YS, Yi BR, Kim NH, Choi KC
- KMID: 2155373
- Exp Mol Med.
- 2014 Aug;46(8):e108.
- doi: 10.1038/emm.2014.44
The epithelial-mesenchymal transition (EMT) is important for embryonic development and the formation of various tissues or organs. However, EMT dysfunction in normal cells leads to diseases, such as cancer or... -
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- Role of PXR and CAR in Cholestasis
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Suh JI
- KMID: 760626
- Korean J Hepatol.
- 2006 Mar;12(1):5-15.
Cholestatic liver diseases are characterized by impairments of bile flows and accumulations of biliary constituents such as bile acids and bilirubin. The changes of phase I and II metabolism and... -
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- Gastrointestinal Metastasis from a Primary Adenocarcinoma of the Lung Presenting with Acute Abdominal Pain
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Hsing CT, Kim HY, Lee JH, Han JS, Lee JH, Chang JS, Choi SR, Jeong JS
- KMID: 1792839
- Korean J Gastroenterol.
- 2012 May;59(5):382-385.
- doi: 10.4166/kjg.2012.59.5.382
Symptomatic gastro-intestinal metastasis in lung cancer is extremely rare and only a few case reports have been published. Here, we report a case with lung adenocarcinoma that presented with acute... -
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- Subpopulations of Regulatory T Cells in Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Behcet's Disease
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Kim JR, Chae JN, Kim SH, Ha JS
- KMID: 1782132
- J Korean Med Sci.
- 2012 Sep;27(9):1009-1013.
- doi: 10.3346/jkms.2012.27.9.1009
Recently, subpopulations of regulatory T (Treg) cells, resting Treg (rTreg) and activated Treg (aTreg), have been discovered. The authors investigated the relationship between the change of Treg, aTreg and rTreg... -
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- Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways
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Shin SH, Lee YM
- KMID: 2154236
- Exp Mol Med.
- 2013 Apr;45(4):e17.
The anti-melanogenesis effect of glyceollins was examined by melanin synthesis, tyrosinase activity assay in zebrafish embryos and in B16F10 melanoma cells. When developing zebrafish embryos were treated with glyceollins, pigmentation... -
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- Composite Follicular Variant of Papillary Carcinoma and Mucoepidermoid Carcinoma of Thyroid Gland: A Case Report
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Jung YH, Kang MS
- KMID: 1779245
- J Korean Med Sci.
- 2010 Nov;25(11):1683-1687.
- doi: 10.3346/jkms.2010.25.11.1683
A 50-yr-old male presented a thyroid mass with dysphasia and hoarseness. He underwent total thyroidectomy and neck node dissection. Pathologically, the tumor had two distinct tumor components with intermingled areas:... -
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- Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin
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Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J, Kim TY
- KMID: 2155352
- Exp Mol Med.
- 2014 Mar;46(3):e87.
- doi: 10.1038/emm.2013.157
Inflammation is a part of the complex biological responses of a tissue to injury that protect the organ by removing injurious stimuli and initiating the healing process, and is considered... -
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- Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1
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Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH
- KMID: 1123464
- Exp Mol Med.
- 2009 Mar;41(3):171-179.
- doi: 10.3858/emm.2009.41.3.020
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in... -
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- Disturbed Osteoblastic Differentiation of Fibrous Hamartoma Cell from Congenital Pseudarthrosis of the Tibia Associated with Neurofibromatosis Type I
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Lee DY, Cho TJ, Lee HR, Lee K, Moon HJ, Park MS, Yoo WJ, Chung CY, Choi IH
- KMID: 1743914
- Clin Orthop Surg.
- 2011 Sep;3(3):230-237.
- doi: 10.4055/cios.2011.3.3.230
BACKGROUND: Fibrous hamartoma is the key pathology of congenital pseudarthrosis of the tibia (CPT), which was shown to have low osteogenicity and high osteoclastogenicity. This study further investigated the mechanism... -
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- Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications
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Kim TH, Kim MY, Jo SH, Park JM, Ahn YH
- KMID: 1727863
- Yonsei Med J.
- 2013 May;54(3):545-559.
- doi: 10.3349/ymj.2013.54.3.545
Peroxisome proliferator-activated receptor gamma (PPARgamma) belongs to a nuclear receptor superfamily; members of which play key roles in the control of body metabolism principally by acting on adipose tissue. Ligands... -
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- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1
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Lee EG, Yun HJ, Lee SI, Yoo WH
- KMID: 1785661
- Korean J Intern Med.
- 2010 Mar;25(1):93-100.
- doi: 10.3904/kjim.2010.25.1.93
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation.... -
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- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
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Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M
- KMID: 2164486
- J Korean Med Sci.
- 2015 Jul;30(7):979-987.
- doi: 10.3346/jkms.2015.30.7.979
Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is... -
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- Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells
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Choi JH, Kim JS, Kim YC, Kim YS, Chung NH, Cho MH
- KMID: 1094683
- J Vet Sci.
- 2004 Mar;5(1):11-18.
Accurate estimation of the exposure-response relationship between ambient urban particulate matters (PM) and public health is important for regulatory perspective of ambient urban particulate matters (PM). Ambient PM contains various... -
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- Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model
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Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY
- KMID: 1711277
- Korean J Gastroenterol.
- 2013 Jul;62(1):33-41.
- doi: 10.4166/kjg.2013.62.1.33
BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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- Factors Influencing the Response to High Dose Methotrexate-based Vincristine and Procarbazine Combination Chemotherapy for Primary Central Nervous System Lymphoma
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Sung KH, Lee EH, Kim YZ
- KMID: 1777887
- J Korean Med Sci.
- 2011 Apr;26(4):551-560.
- doi: 10.3346/jkms.2011.26.4.551
The authors investigated objective response rate to high dose methotrexate (HDMTX)-based combination chemotherapy in primary central nervous system lymphoma (PCNSL), and sought to identify factors that influence response to HDMTX-based... -
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- Regulation of Inhibitors of Differentiation Family Proteins by Thyroid-Stimulating Hormone in FRTL-5 Thyroid Cells
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Jo YS, Hwang ES, Lee JH, Lee Y, Kim SY, Choi YS, Bai YS, Hong JH, Kim YJ, Lee IS, Rha SY, Ro HK, Shong M
- KMID: 1713459
- J Korean Med Sci.
- 2008 Apr;23(2):262-269.
- doi: 10.3346/jkms.2008.23.2.262
Members of the inhibitors of differentiation (Id) family of helix-loop-helix (HLH) proteins are known to play important roles in the proliferation and differentiation of many cell types. Thyroid-stimulating hormone (TSH)... -
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