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Water soluble tomato concentrate regulates platelet function via the mitogen-activated protein kinase pathway

Jeong D, Irfan M, Saba E, Kim SD, Kim SH, Rhee MH

Tomato extract has been shown to exert antiplatelet activity in vitro and to change platelet function ex vivo, but with limitations. In this study, antiplatelet activity of water soluble tomato...
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Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation

Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Lee SP, Kang MH, Choi EK, Rhee MH, Kim YB

  • KMID: 2312116
  • Lab Anim Res.
  • 2014 Mar;30(1):21-27.
The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma...
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Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation

Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Park SK, Lee SP, Choi EK, Rhee MH, Kim YB

The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers...
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Implication of aspirin resistance: Simple laboratory finding or important clinical criteria?

Jeong YH

  • KMID: 2257262
  • Korean J Med.
  • 2009 Jun;76(6):682-684.
Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care...
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Age-Related Changes of Lipid Metabolism and Thrombogenic Capacity in Rats

Um MY, Rho KA, Kim MK

  • KMID: 2269793
  • Korean J Nutr.
  • 2004 Sep;37(7):525-532.
This study was performed to investigate the age-related changes of the lipid metabolism and thrombogenic capacity in Sprague-Dawley (SD) rats at the ages of 4, 8, 12, 16, 20 and...
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Effect of Dried Powders or Ethanol Extracts of Garlic Flesh and Peel on Lipid Metabolism and Antithrombogenic Capacity in 16-Month-Old Rats

Shin SH, Kim MK

  • KMID: 2269792
  • Korean J Nutr.
  • 2004 Sep;37(7):515-524.
This study was performed to investigate effect of dried powders and ethanol extracts of garlic flesh and peel on lipid metabolism and antithrombogenic capacity in 16-month-old rats. Forty Sprague-Dawley male...
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Effects of Propofol on Endotoxin-Induced Acute Lung Injury in Rabbit

Kwak SH, Choi JI, Park JT

This study was undertaken to clarify the effects of propofol on endotoxin-induced acute lung injury. Rabbits were randomly assigned to one of four groups. Each group received intravenous infusion of...
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The Change of Histologic Features and Eicosanoids Level in Rat Testicular Ischemia-Reperfusion Injury

Lee SJ, Lee GH, Kim HJ, Kim HG, Kim EJ

  • KMID: 2292529
  • Korean J Urol.
  • 2002 Dec;43(12):1086-1092.
PURPOSE: It has been suggested that prostaglandins (PGs) play an important role in ischemia-reperfusion (IR) organ injury. However, the significance of PGs is not well documented for a testicular IR...
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The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB2 Level in Korean Postmenopausal Women with Hypercholesterolemia

Jung K, Kim S, Woo J, Chang Y

The purpose of this study was to observe the effects of dietary intervention, through the modification of dietary fatty acids composition and antioxidant vitamins, on plasma thromboxane B2 (TXB2) levels...
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Effect of Leukotriene B4 and Thromboxane B2 on Lumbar Nerve Roots in Rat

Baek DH, Jahng J, Ha KY

  • KMID: 2322845
  • J Korean Soc Spine Surg.
  • 2001 Mar;8(1):8-14.
STUDY DESIGN: The motor impairment and sensory dysfunction were evaluated in twenty-eight rats after dropping of leukotriene B4 and thromboxane B2 on lumbar nerve roots. OBJECTIVES: To evaluate the effects...
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The effect of indomethacin on the production of eicosanoids and edema during ischemia-reperfusion injury in skeletal muscle

Chung YJ, Sohn BK, Hyun KS, Yoo SH, Ryu HK, Kim HG

  • KMID: 1581031
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):525-530.
During reperfusion of skeletal muscle after ischemia, lipid mediators, mainly eicosanoids, are released and may have a role in the pathogenesis of reperfusion injury. To validate the role of eicosanoids in the ischemia-reperfusion...
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Effect of Aprotinin on Changes in Plasma Thromboxane B2 and Endothelin-1 Concentratin after Extracorporeal Circulation

Lim C, Yun TC, Kim YS, Kim SH, Lee JD, Rho JR, Song MK

  • KMID: 1581859
  • Korean J Thorac Cardiovasc Surg.
  • 2000 Mar;33(3):221-229.
BACKGROUND: Thromboxane A2 and endothelin-1 are the potent vasoconstrictors affecting pulmonary pathophysiology in response to whole body inflammatin following CPB. Aprotinin, as an antiiflammatory agent, may decrease the release of such vasoactive...
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The Production of Prostaglandin , Thromboxane and Cytokines in Human Term Decidual Cell Fraction by NG-nitro-L-arginine methyl ester Stimulation

Park MH, Kim YK, Chun SH, Kim JI, Ahn JJ, Seo JY

  • KMID: 2075827
  • Korean J Obstet Gynecol.
  • 1999 Jul;42(7):1513-1522.
BACKGROUND: The mechanism that maintains relative uterine quiescence during pregnancy remains almost unknown, but probably involves a complex balance of inhibitory and stimulatory factors. In the last few years, a...
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Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • KMID: 2071837
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
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The Effect of The Coadministration of Vitamin E in Cyclosporine A(CsA) Induced Acute Nephrotoxicity in Rats

Shin ES, Kim YW, Kim YJ, Park YH

  • KMID: 2198894
  • J Korean Soc Transplant.
  • 1997 May;11(1):11-20.
Cyclosporine A(CsA) induced nephrotoxicity is a common clinical problem in the patients who underwent organ transplantation and subsequent immunosuppressive therapy. The precise pathophysiology of CsA induced nephrotoxicity still remains uncertain...
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Effect of triflusal on the platelet aggregation in human whole blood

Lee HS, Kang KS, Lee BC, Yu KH

  • KMID: 2342586
  • J Korean Neurol Assoc.
  • 1997 Feb;15(1):60-66.
BACKGROUND AND PURPOSE: Triflusal(TR), 2-acetoxy-4-trifluoromethyl banzoic acid, is a platelet aggregation inhibitor structurally related to aspirin, proven to possess both in vitro and in vivo platelet antiaggregatoy activity. The aim...
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6-ketoprostaglandin F_(12) and thromboxane B2 concentrations of maternal blood in pregnancy induced hypertension

Yang JY, Park HJ, Jang KS, Kim YH, Byun JS

  • KMID: 1688701
  • Chonnam Med J.
  • 1993 Jun;30(1):83-91.
No abstract available.
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The Effect of Indomethacin Pretreatment Before Nd:YAG Laser Anterior Capsulotomy on Intraoular Pressure of Rabbits

Myong YW, Baek NH, Rhee SW

  • KMID: 2123226
  • J Korean Ophthalmol Soc.
  • 1993 May;34(5):408-417.
To evaluate the cause of intraocular pressure elevation and the effect of indomethacin after Nd:YAG laser anterior capsulotomy in rabbit authors measured the intraocular pressure, prostaglandin E2 and thromboxane B2...
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Inhibition of prostaglandin F2 and thromboxane B2 synthesis in electrically injured tissue by flurbiprofen, prednisolone and gabexate mesilate

Cho BC, Kim IK, Byun JS, Baik BS

  • KMID: 2119218
  • J Korean Soc Plast Reconstr Surg.
  • 1991 Jan;18(1):75-87.
No abstract available.
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Evaluation of Cerebrospinal Fluid Levels of Thromboxane B2 and 6-ketoprostaglandin F1alpha in Patients with Aneurysmal Subarachnoid Hemorrhage

Kim SY, Yim MB, Son EI, Kim IH, Lee IK

  • KMID: 2067786
  • J Korean Neurosurg Soc.
  • 1989 May;18(5):671-679.
In order to find out the relationship between arachidonic acid(AA) metabolites and the development of vasospasm following a subarachnoid hemorrhage(SAH), we evaluated the cerebrospinal fluid(CSF) levels of the two main...
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