Lab Anim Res.  2014 Mar;30(1):21-27.

Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation

Affiliations
  • 1College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar93@cbu.ac.kr rheemh@knu.ac.kr
  • 2Misuba RTech Co., Ltd., Asan, Korea.
  • 3Department of Food Science and Nutrition, Hoseo University, Asan, Korea.
  • 4College of Veterinary Medicine, Kyungpook National University, Daegu, Korea. solar93@cbu.ac.kr rheemh@knu.ac.kr

Abstract

The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B2 formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.

Keyword

Platelet aggregation; thromboxane B2; thrombosis; perilla oil

MeSH Terms

Animals
Aspirin
Blood Platelets*
Collagen
Perilla*
Platelet Aggregation*
Platelet-Rich Plasma
Rats
Thrombin
Thrombosis*
Thromboxane B2
Aspirin
Collagen
Thrombin
Thromboxane B2
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