Lab Anim Res.  2016 Sep;32(3):171-179. 10.5625/lar.2016.32.3.171.

Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet

Affiliations
  • 1College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar93@cbu.ac.kr vertebrate@hanmail.net
  • 2Anydoctor Healthcare Co., Ltd., Cheonan, Korea.

Abstract

Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation. Perilla oil not only attenuated hypercholesterolemia and atheroma formation, but also reduced fat accumulation and lipid peroxidation in hepatic and renal tissues. The results indicate that perilla oil prevents atherosclerosis and fatty liver by controlling lipid metabolism, and that it could be the first choice oil to improve diet-induced metabolic syndrome.

Keyword

Hypercholesterolemia; atherosclerosis; fatty liver; lipid peroxidation; perilla oil

MeSH Terms

Atherosclerosis
Cholesterol
Corn Oil
Diet*
Fatty Liver
Hypercholesterolemia
Kidney
Lipid Metabolism
Lipid Peroxidation
Lipoproteins, LDL
Liver
Lovastatin
Perilla*
Plaque, Atherosclerotic
Rabbits*
Cholesterol
Corn Oil
Lipoproteins, LDL
Lovastatin
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