J Korean Med Sci.  2002 Jun;17(3):307-315. 10.3346/jkms.2002.17.3.307.

The Effect of Dietary Intervention Through the Modification of Fatty Acids Composition and Antioxidant Vitamin Intake on Plasma TXB2 Level in Korean Postmenopausal Women with Hypercholesterolemia

• Jung K
• Kim S
• Woo J
• Chang Y

• KMID: 1101543
• DOI: http://doi.org/10.3346/jkms.2002.17.3.307

Abstract

The purpose of this study was to observe the effects of dietary intervention, through the modification of dietary fatty acids composition and antioxidant vitamins, on plasma thromboxane B2 (TXB2) levels in postmenopausal women with hypercholesterolemia. The subjects were treated for 12 weeks with one of three methods: hormone replacement therapy (HRT group, n=8), dietary intervention (DIET group, n=8), or HRT combined with dietary intervention (HRT +DIET group, n=8). Changes in serum phospholipid fatty acids composition, serum peroxides, and plasma TXB2 levels were measured at weeks 0, 4 and 12. The P/S ratio increased and the n-6/ n-3 ratio decreased in the DIET and the HRT +DIET group at week 4 (p<0.05). The ratio of C20:5/C20:4 in serum phospholipid increased in the DIET (p<0.05) and the HRT +DIET groups (NS) at week 4. Plasma TXB2 levels decreased in the DIET (-35%, p<0.05) and the HRT +DIET groups (-18.8%, NS) at week 4. Serum lipid peroxides levels significantly decreased by 10.5% and 15.2% in the DIET group at weeks 4 and 12, and by 10.8% in the HRT +DIET group only at week 12 (p<0.05). Dietary intervention may lower thrombotic risks in Korean postmenopausal women by changing the serum fatty acid composition, serum lipid peroxides levels and plasma thromboxane B2 levels.

Keyword

Postmenopause; Thromboxane B2; Lipid peroxides; Fatty Acids; Antioxidants

MeSH Terms

Antioxidants/*administration & dosage/metabolism
Ascorbic Acid/*administration & dosage/blood
Dietary Fats/administration & dosage/blood
Estrogen Replacement Therapy
Fatty Acids/*administration & dosage/blood
Female
Humans
Hypercholesterolemia/blood/*drug therapy
Lipid Peroxidation
Middle Aged
Postmenopause
Thromboxane B2/*blood
Vitamin A/administration & dosage/blood
Vitamin E/administration & dosage/blood