J Korean Soc Clin Pharmacol Ther.  2011 Dec;19(2):166-179.

Analysis of Plasma Long-Chain Fatty Acids in Hypertensive Patients

• Kim JS
• Kwon GY
• Kim SK

Abstract

BACKGROUND
Numerous studies have suggested that polyunsaturated fatty acids (PUFAs)-supplemented diets may decrease cardiovascular morbidity and mortality. Especially, omega-3 PUFAs may exert beneficial effects to the treatment and prevention of dyslipidemias, arrhythmias, atherosclerosis, and hypertension.
METHODS
This study investigated plasma lipid profiles including total cholesterol, triglycerides (TG), LDL, HDL, and antioxidant status indicative of vitamin A, vitamin E, malondialdehyde (MDA) and distribution of plasma long-chain fatty acids (C12-C24) in 28 normal subjects and 24 hypertensive patients. Also, the correlation among PUFAs, levels of antioxidant status, and lipid profiles of the subjects were estimated.
RESULTS
The distribution of omega-3 PUFAs, saturated fatty acids, and monounsaturated fatty acids showed significant differences (P<0.05), but that of omega-6 PUFAs did not exhibit significant differences. The omega-6/omega-3 ratio exhibited 36.96 in normal group and 14.29 in the hypertensive patient group. The levels of vitamin A, vitamin E, and MDA were increased significantly in the hypertensive patient group.
CONCLUSION
PUFA levels were estimated in the hypertensive patients and normal group. The results suggest that dietary intake of proper omega-6/omega-3 ratio is needed for prevention and treatment of hypertension.

Keyword

Plasma long-chain fatty acids; Hypertensive patients

MeSH Terms

Arrhythmias, Cardiac
Atherosclerosis
Cholesterol
Diet
Dyslipidemias
Fatty Acids
Fatty Acids, Monounsaturated
Fatty Acids, Unsaturated
Humans
Hypertension
Malondialdehyde
Plasma
Triglycerides
Vitamin A
Vitamin E
Vitamins
Cholesterol
Fatty Acids
Fatty Acids, Monounsaturated
Fatty Acids, Unsaturated
Malondialdehyde
Triglycerides
Vitamin A
Vitamin E
Vitamins