J Korean Neurol Assoc.  1997 Feb;15(1):60-66.

Effect of triflusal on the platelet aggregation in human whole blood

• Lee HS
• Kang KS
• Lee BC
• Yu KH

Abstract

BACKGROUND AND PURPOSE: Triflusal(TR), 2-acetoxy-4-trifluoromethyl banzoic acid, is a platelet aggregation inhibitor structurally related to aspirin, proven to possess both in vitro and in vivo platelet antiaggregatoy activity. The aim of this study was to evaluate the effect of TR with different dosages on platelet function using platelet aggregation, adenosine triphosphate (ATP) secretion, and thromboxane generation after TR administration.
METHODS
Twenty healthy volunteers (age 25-41years, 15 males 5 females) were randomly divided into two groups of ten subjects who were receiving one of two regimens (TR 300mg/day; TR 900mg/day) for seven days. Platelet functions including platelet aggregation by impedance methods using whole blood with ADP (5, 10uM) and collagen (1,2uM), ATP secretion and thromboxane B2 generation were determined.
RESULTS
The inhibitory effect of platelet aggregation was observed in both groups. The degree of inhibitory effect was depended on the dosage of TR and the types of aggregating agent. Thromboxane B2 concentrations were significantly decreased by TR ingestion in both groups (p<0.01), but there was no differences in ATP secretion.
CONCLUSIONS
This study show that TR exerts a remarkable platelet antiaggregation effect and inhibition of thromboxane synthesis in whole blood. In addition, the fact that TR does not affect ATP secretion means selective blocking of the platelet cyclooxygenase pathway.

MeSH Terms

Adenosine Diphosphate
Adenosine Triphosphate
Aspirin
Blood Platelets*
Collagen
Eating
Electric Impedance
Healthy Volunteers
Humans*
Male
Platelet Aggregation*
Prostaglandin-Endoperoxide Synthases
Thromboxane B2
Adenosine Diphosphate
Adenosine Triphosphate
Aspirin
Collagen
Prostaglandin-Endoperoxide Synthases
Thromboxane B2