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Characterization of the distinct mechanism of agonist-induced canine platelet activation

Chaudhary , Kim S

Platelet activation has a major role in hemostasis and thrombosis. Various agonists including adenosine diphosphate (ADP) and thrombin interact with G protein-coupled receptors (GPCRs) which transduce signals through various G...
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Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Kobayashi , Banno K, Kunitomi H, Tominaga E, Aoki D

Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the...
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Methanol Extracts of Codium fragile Induces Apoptosis through G1/S Cell Cycle Arrest in FaDu Human Hypopharynx Squamous Carcinoma Cells

Lee SA, Park BR, Moon SM, Kim DK, Kim CS

Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria....
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The Anti-fibrotic Effect of Nilotinib on Tenon's Capsule Fibroblasts in Vitro

Kang JW, Jeong JH, Moon NJ

PURPOSE: To evaluate the anti-fibrotic effects of nilotinib on the survival of cultured human Tenon's capsule fibroblasts (HTFs). METHODS: HTF primary cultures were obtained from samples following glaucoma surgery. Primarily cultured...
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Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment

Joo HJ, Park JY, Hong SJ, Kim KA, Lee SH, Cho JY, Park JH, Yu CW, Lim DS

BACKGROUND/AIMS: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in...
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Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide

Lee AY, Choi JM, Lee MH, Lee J, Lee S, Cho EJ

BACKGROUND/OBJECTIVE: Oxidative stress plays a key role in neuronal cell damage, which is associated with neurodegenerative disease. The aim of present study was to investigate the neuroprotective effects of perilla...
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Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⁺ signaling in ventricular myocytes

Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG

Cyclic ADP-ribose (cADPR) releases Ca²⁺ from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of...
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Antiplatelet Therapy Combinations and Thrombogenicity in Patients with Non-Valvular Atrial Fibrillation

Park Y, Kim KH, Kang MG, Ahn JH, Jang JY, Park HW, Koh JS, Park JR, Hwang SJ, Jeong YH, Hwang JY, Lee HR, Kwak CH

BACKGROUND AND OBJECTIVES: Combination antiplatelet therapy reduces the risk of ischemic stroke compared with aspirin monotherapy in non-valvular atrial fibrillation (NVAF) patients. The underlying mechanism, however, remains unclear. In addition,...
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Mitochondrial Metabolic Inhibition and Cardioprotection

Lee SR, Han J

No abstract available.
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Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity

Yoon SP, Kim J

Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain...
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Water soluble tomato concentrate regulates platelet function via the mitogen-activated protein kinase pathway

Jeong D, Irfan M, Saba E, Kim SD, Kim SH, Rhee MH

Tomato extract has been shown to exert antiplatelet activity in vitro and to change platelet function ex vivo, but with limitations. In this study, antiplatelet activity of water soluble tomato...
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Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells

Song H, Yoon SP, Kim J

After renal injury, selective damage occurs in the proximal tubules as a result of inhibition of glycolysis. The molecular mechanism of damage is not known. Poly(ADP-ribose) polymerase (PARP) activation plays...
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Monitoring the Antiplatelet Effect of Cilostazol with Light Transmission Aggregometer: Two Cases of Possible Cilostazol Resistance

Shim H, Jang S, Park CJ, Chi HS, Lee SW, Park SW

BACKGROUND: Coronary artery disease is an important cause of death in adults and stent insertion is one of the treatment modalities. The most severe adverse effect of a stent insertion...
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Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells

Lee HM, Moon A

Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor...
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An Assay of Measuring Platelet Reactivity Using Monoclonal Antibody against Activated Platelet Glycoprotein IIb/IIIa in Patients Taking Clopidogrel

Joo SJ, Choi JH, Kim SY, Kim KS, Kim YR, Kang SH

BACKGROUND AND OBJECTIVES: Residual platelet reactivity in patients who are taking clopidogrel is commonly measured with VerifyNow assay, which is based on the principle of light transmission aggregometry. However, to...
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A Case of Agenesis of the Dorsal Pancreas with Concomitant Pancreatic Ductal Adenocarcinoma in an Adult Patient

Park JE, Jung SY, Lee JY, Lee EH, Goag EK, Lee SH, Cha BH

Agenesis of dorsal pancreas (ADP) is an extremely rare congenital anomaly defined as an absence of the dorsal ductal system resulting from failure in the embryologic development of the pancreatic...
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Inhibitory Effects of Yuzu and Its Components on Human Platelet Aggregation

Kim TH, Kim HM, Park SW, Jung YS

Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human...
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Guideline for the prevention and management of particulate matter/Asian dust particle-induced adverse health effect on the patients with pulmonary diseases

Kyung SY, Kim YS, Kim WJ, Park MS, Song JW, Yum H, Yoon HK, Rhee CK, Jeong SH

The aim of this study was to develop guidelines for the prevention and management of particulate matter (PM)/Asian dust particle (ADP)-induced adverse effects in patients with pulmonary diseases. The guideline...
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Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation

Chin N, Rangamuwa , Mariasoosai R, Carnes J, Thien F

Oral platelet aggregation inhibitors are widely used for the treatment and prevention of cardiovascular diseases, including coronary stent thrombosis. Premature discontinuation following percutaneous coronary intervention would pose a grave risk...
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Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid

Kim M, Han CH, Lee MY

  • KMID: 2170644
  • Biomol Ther.
  • 2014 May;22(3):254-259.
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact...
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