- Effects of Cytokines on Proliferation Responses of Th1 Cells to Mitogen
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Ha TY, Lee MY, Jung SW
- KMID: 1547842
- Korean J Immunol.
- 1997 Mar;19(1):73-82.
Thl cloned cell line 28-4 which is an I-A + KLH - specific Th1 type clone of (C57BU6xC 3H) F1 origin was kindly provided by professor Tomio Tada. In these... -
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- Peripheral Th1 and Th2 Lymphocytes Values by Intracellular Cytokine Staining for Interferon-and Interleukin-4 in the Patients with Repeated Spontaneous Abortion
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Park AJ, Lee MK
- KMID: 2038246
- Korean J Lab Med.
- 2005 Apr;25(2):111-115.
BACKGROUND: In the women who experienced recurrent spontaneous abortions (RSA), cellular immune abnormalities of peripheral blood Natural Killer (NK) cell have been reported and the imbalance of Th1 and Th2... -
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- Regulation and Function of Th17 Cells
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- KMID: 2090204
- Korean J Asthma Allergy Clin Immunol.
- 2011 Mar;31(1):1-8.
Naive CD4+ helper T (Th) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effecter cells that are characterized by their distinct cytokine production profiles and immune... -
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- Anti-proliferative Activity of T-bet
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Oh YJ, Shin JH, Won HY, Hwang ES
- KMID: 2168047
- Immune Netw.
- 2015 Aug;15(4):199-205.
- doi: 10.4110/in.2015.15.4.199
T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4+ precursor cells. Since T-bet directly binds to the promoter of the IFN-gamma gene and activates its... -
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- Regulation of Th2 Cell Immunity by Dendritic Cells
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Na H, Cho M, Chung Y
- KMID: 2154806
- Immune Netw.
- 2016 Feb;16(1):1-12.
- doi: 10.4110/in.2016.16.1.1
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which... -
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- Th17 Responses Are Not Induced in Dextran Sodium Sulfate Model of Acute Colitis
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Kim YS, Lee MH, Ju AS, Rhee KJ
- KMID: 2150729
- Immune Netw.
- 2011 Dec;11(6):416-419.
- doi: 10.4110/in.2011.11.6.416
Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD.... -
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- B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
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Choi Y, Kim JJ
- KMID: 1093611
- Exp Mol Med.
- 2003 Oct;35(5):385-392.
Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we... -
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- T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice
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Kaminuma O, Nishimura , Kitamura N, Saeki M, Hiroi T, Mori A
- KMID: 2428852
- Allergy Asthma Immunol Res.
- 2018 Jan;10(1):77-82.
- doi: 10.4168/aair.2018.10.1.77
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation... -
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- Genetic controls of Th17 cell differentiation and plasticity
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Dong C
- KMID: 991617
- Exp Mol Med.
- 2011 Jan;43(1):1-6.
- doi: 10.3858/emm.2011.43.1.007
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2... -
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- Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
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Yoon SH, Yun SO, Park JY, Won HY, Kim EK, Sohn HJ, Cho HI, Kim TG
- KMID: 1123463
- Exp Mol Med.
- 2009 Mar;41(3):161-170.
- doi: 10.3858/emm.2009.41.3.019
Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on... -
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- Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7− and α4β1+α6β1−α4β7+ Cells
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Yang JI, Park C, Kho I, Lee S, Suh KS, Kim TJ
- KMID: 2400625
- Immune Netw.
- 2017 Dec;17(6):392-401.
- doi: 10.4110/in.2017.17.6.392
We previously reported peritoneal innate-like integrin α4 (CD49d)highCD4+ T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural... -
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- Production of interferon-gamma and interleukin-4 by splenocytes in mice infected with Paragonimus westermani
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Shin MH, Min DY
- KMID: 1715354
- Korean J Parasitol.
- 1996 Sep;34(3):185-189.
- doi: 10.3347/kjp.1996.34.3.185
The TH cytokine responses of spleen cells stimulated with Con A from mice infected with Paragonimus westermani were examined. The spleen cell culture supernatants were assayed for TH1-specific IFN-gamma and... -
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- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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- The Effect of Interleukin-12 on the Immune Response in Allergic Rhinitis Mouse Model
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Kang SM, Ryu HY, Lee JH
- KMID: 2314241
- Pediatr Allergy Respir Dis.
- 2001 Sep;11(3):213-223.
PURPOSE: Interleukin-12, produced by tissue macrophages and B lymphocytes, stimulates proliferation of Th1-type cells, while inhibiting the generation of Th2- type cytokines and IgE production. The mice were sensitized and... -
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- Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis
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Kim J, Kang S, Kim J, Kwon G, Koo S
- KMID: 1781298
- Ann Lab Med.
- 2013 Jan;33(1):52-59.
- doi: 10.3343/alm.2013.33.1.52
BACKGROUND: Interleukin-17 (IL-17)-producing T helper (Th) 17 cells are considered as a new subset of cells critical to the development of rheumatoid arthritis (RA). We aimed to investigate the distribution... -
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- Mycobacterium vaccae induces a strong Th1 response that subsequently declines in C57BL/6 mice
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Zhang L, Jiang Y, Cui Z, Yang W, Yue L, Ma Y, Shi S, Wang C, Wang C, Qian A
- KMID: 2412606
- J Vet Sci.
- 2016 Dec;17(4):505-513.
- doi: 10.4142/jvs.2016.17.4.505
Mycobacterium (M.) vaccae is a fast-growing species of saprophytic bacteria that is widely distributed. To understand the host immune responses induced by M. vaccae isolated from bovine submaxillary lymph nodes,... -
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- Changes of cytokine mRNA expression and IgG responses in rats infected with Capillaria hepatica
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Kim DK, Joo KH, Chung MS
- KMID: 1720532
- Korean J Parasitol.
- 2007 Jun;45(2):95-102.
- doi: 10.3347/kjp.2007.45.2.95
The mRNA expression of several cytokines was evaluated in splenocytes and mesenteric lymph node (MLN) cells of rats infected with Capillaria hepatica by reverse-transcription (RT)-PCR until week 12 after infection.... -
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- Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
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Kim HJ, Baek J, Lee JR, Roh JY, Jung Y
- KMID: 2410159
- Immune Netw.
- 2018 Apr;18(2):e9.
- doi: 10.4110/in.2018.18.e9
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine... -
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- Limited Effect of CpG ODN in Preventing Type 1 Diabetes in NOD Mice
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Lee BJ, Kim SK, Kim MK, Park ES, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH
- KMID: 1734067
- Yonsei Med J.
- 2005 Jun;46(3):341-346.
- doi: 10.3349/ymj.2005.46.3.341
Type 1 diabetes is considered as Th1 cell mediated autoimmune disease and the suppression of Th1 cells or the activation of Th2 cells has been regarded as a plausible immunologic... -
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- The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4+CD25+ T Cells
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Lee MJ, Heo YM, Hong SH, Kim K, Park S
- KMID: 1474596
- Immune Netw.
- 2009 Apr;9(2):58-63.
- doi: 10.4110/in.2009.9.2.58
BACKGROUND: T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown... -
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