Immune Netw.  2016 Feb;16(1):1-12. 10.4110/in.2016.16.1.1.

Regulation of Th2 Cell Immunity by Dendritic Cells

Affiliations
  • 1Laboratory of Immune Regulation, Research Institute for Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea. mkcho84@snu.ac.kr, yeonseok@snu.ac.kr

Abstract

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.

Keyword

Th2 cell; Dendritic cell; PDL2; CD301b; Allergic inflammation
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