Korean J Pediatr.  2005 Jan;48(1):6-12.

Helper T Cell Polarizing Through Dendritic Cells

• Han M

Abstract

In the last few years, a spectrum of dendritic cells(DCs), including toll like receptors(TLRs), might play a critical role in regulating allergy and asthma. DC plays a central role in initiating immune responses, linking innate and adaptive responses to pathogen. Human peripheral blood has three non- overlapping dendritic subset that expressed various 11 TLRs. These dendritic subsets and TLR contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. A better understanding of DC immunobiology may lead to the comprehension of allergy pathophysiology to prevent early stage allergic march.

Keyword

Toll like receptor; Plasmacytoid dendritic cell; Myeloid dendritic cell; Th1/Th2 deviation

MeSH Terms

Asthma
Comprehension
Dendritic Cells*
Humans
Hypersensitivity
Toll-Like Receptors
Toll-Like Receptors