Korean J Intern Med.
2018 May;33(3):483-489. 10.3904/kjim.2016.227.
Fundamental role of dendritic cells in inducing Th2 responses
- Affiliations
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- 1Department of Otorhinolaryngology-Head & Neck Surgery, Korea University College of Medicine, Seoul, Korea. doctorth@korea.ac.kr
- 2Neuroscience Research Institute, Korea University College of Medicine, Seoul, Korea.
- 3Allergy Immunology Center, Korea University College of Medicine, Seoul, Korea.
- KMID: 2411574
- DOI: http://doi.org/10.3904/kjim.2016.227
Abstract
- A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, particularly dendritic cells (DCs), are mandatory for the induction of a Th cell response. Numerous studies have documented the organizing role of DCs in this process. The present review summarizes the fundamental roles of DCs in inducing Th2 responses.
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