J Pathol Transl Med.  2018 Jul;52(4):243-247. 10.4132/jptm.2018.03.27.

Recurrent Indeterminate Dendritic Cell Tumor of the Skin

• Joo JW
• Chung T
• Cho YA
• Kim SK

• KMID: 2417809
• DOI: http://doi.org/10.4132/jptm.2018.03.27

Abstract

Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred three months after surgical excision.

Keyword

Indeterminate dendritic cell tumor; Skin tumor; Recurrence

MeSH Terms

Dendritic Cells*
Humans
Immunohistochemistry
Langerhans Cells
Middle Aged
Recurrence
Skin*

Figure

• 

  Fig. 1. Physical and gross findings. (A) Four erythematous papules on the patient’s back. (B) The largest papule. (C) Gross examination of the largest nodule involving the dermis and subcutis.

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  Fig. 2. Histologic findings. (A) Scan power view of the largest nodule. (B) A solid growth of epithelioid cells with infiltrative borders. (C) Epithelioid cells with moderate nuclear atypia and irregular folded nuclei. (D) Frequent mitoses and a few scattered multi-nucleated giant cells.

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  Fig. 3. The immunohistochemical stain results. Immunohistochemical panels of S100 (A), CD1a (B), Langerin (C), and CD68 (D).

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