Ann Dermatol.  2017 Oct;29(5):614-617. 10.5021/ad.2017.29.5.614.

Aggressive Indeterminate Dendritic Cell Tumor Mimicking Scalp Angiosarcoma

• Li Y
• Wang TT
• Zhang ZH
• Wang L

• KMID: 2388914
• DOI: http://doi.org/10.5021/ad.2017.29.5.614

Abstract

Indeterminate dendritic cell tumor (IDCT) is a proliferation of CD1a+, S100+ and langerin- histiocytes with a generally benign course. Here, we describe a case of a 90-year-old male who developed skin lesions on his scalp mimicking angiosarcoma and lymphadenopathy. He died six months after the onset of skin lesions despite of months' radiotherapy. Pathological examination ruled out scalp angiosarcoma and showed a high Ki-67 index. The appearance of skin lesions and lymphadenopathy led to challenges in diagnosis and the development of a treatment plan.

Keyword

Hemangiosarcoma; Indeterminate dendritic cell tumor

MeSH Terms

Aged, 80 and over
Dendritic Cells*
Diagnosis
Hemangiosarcoma*
Histiocytes
Humans
Lymphatic Diseases
Male
Radiotherapy
Scalp*
Skin

Figure

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  Fig. 1 Multiple violaceous confluent papules, nodules and plaques with a central hemorrhagic crust mimicking angiosarcoma.

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  Fig. 2 (A) Hyperkeratosis of the epidermis and tumor nodules in dermis (H&E, ×100). (B) Medium-sized tumor cells with abundant eosinophilic cytoplasm. Reniform nuclei and delicate nuclear grooves are indicated by white arrows (H&E, ×400).

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  Fig. 3 Immunostaining showing that neoplasm cells were (A) CD1a positive (×200), (B) S100 positive (×200), (C) CD31 positive (×200), and (D) Langerin negative (×400).

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  Fig. 4 Computed tomography image showing nodules in the right carotid sheath region (arrows).

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